The need to counteract the dramatic decrease in LH observed in the GnRH-nts cycle has been proposed. No large prospective study is yet published comparing patients treated with GnRH-nt in which LH activity was added. LH activity could be added by the adjunction of rec-LH or by a small dose of hCG (70). It could also be obtained by using hMG. Profound suppression of LH was not found to be associated with lower pregnancy rates (71). No significant advantage was found by adding rec-LH on a systematic basis in GnRH-nts single and multiple-dose protocols (72,73). This remains to be confirmed in large published studies.
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