Single Dose

Figure 1 Gonadotropin-releasing hormone antagonist multiple- and single-dose protocols. Fixed day regimens. Abbreviations: FSH, follicle-stimulating hormone; hMG, human menopausal gonadotropin; hCG, human chorionic gonadotropin.

ovarian stimulation (COH). In the multiple-dose protocol, small doses (0.25 mg) of the GnRH-nt are injected in the middle of the follicular phase (7-9). In the single-dose protocol, a higher dose (3mg) is injected during the late follicular phase, when the LH surge is most feared (10,11).

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