IVM and Preimplantation Genetic Diagnosis

Preimplantation genetic diagnosis (PGD) is a procedure whereby embryos produced by couples who are at risk of having children with an inherited disease or genetic defect, or by patients who have had three or more unexplained miscarriages, can be tested prior to implantation. Couples can therefore choose to have only those embryos diagnosed as being unaffected implanted in the woman's uterus, thus improving the chances of a successful pregnancy. IVF is normally necessary for patients who elect to undergo this procedure in order to generate multiple embryos for genetic analysis. We have recently used IVM as an alternative for selected patients with PCO/PCOS who require PGD so as to avoid the side effects of fertility-drug administration and avoid the risk of OHSS. We recently treated a 35-year-old patient with recurrent miscarriage who had been unsuccessfully treated with two IUI and two IVF cycles in Germany. We collected one MII and 14 GV oocytes and biopsied eight embryos generated. After the transfer of two normal embryos following aneuploidy screening, she became pregnant and we had the world's first live birth after combined IVM and PGD (50).

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