The research into maturation of immature oocytes initiated by Pincus and Enzmann (8) and continued by Edwards et al. (23) was not incorporated as a treatment for human infertility until 1991. Cha et al. (24) reported that human follicular oocytes were harvested from unstimulated ovaries during gynecological surgery, matured in vitro, then fertilized, and five embryos were transferred to a woman with premature ovarian failure. The recipient subsequently delivered healthy triplet girls. Trounson et al. (25) further suggested that immature oocyte recovery could be developed as a new method for the treatment of women with infertility due to PCO because the oocytes of these patients retain their maturational and developmental competence. However, the initial reported IVM pregnancy rates were low. Our group demonstrated that priming with hCG 36 hours prior to immature oocyte collection significantly improved the maturation rate, and the pregnancy rate exceeded 30% (26,27). IVM was initially considered as a treatment for patients with PCOS, but the indications are now expanding to include various other fertility problems.
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