Tissue Structure Alterations

In vivo experimental studies on swine intervertebral discs and in vitro tests on human discs with intradiscal administration of an O2-O3 mixture (at a concentration of 27 ^g/mL) demonstrated dehydration of the fibrillary matrix of the nucleus pulposus that disclosed the collagen mesh/ network and regressive events of fragmentation and vacuole formation. Neuroangiogenesis was sometimes present, with mild hyperplasia of the chondrocytes in the matrix periphery. Such changes are thought to be due to the decomposition of ozone accompanied by the release of free radicals that act directly on the disc matrix or indirectly via proteolytic enzymes (Figure 19.4).

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Essentials of Human Physiology

Essentials of Human Physiology

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