In vivo experimental studies on swine intervertebral discs and in vitro tests on human discs with intradiscal administration of an O2-O3 mixture (at a concentration of 27 ^g/mL) demonstrated dehydration of the fibrillary matrix of the nucleus pulposus that disclosed the collagen mesh/ network and regressive events of fragmentation and vacuole formation. Neuroangiogenesis was sometimes present, with mild hyperplasia of the chondrocytes in the matrix periphery. Such changes are thought to be due to the decomposition of ozone accompanied by the release of free radicals that act directly on the disc matrix or indirectly via proteolytic enzymes (Figure 19.4).
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Deal With Your Pain, Lead A Wonderful Life An Live Like A 'Normal' Person. Before I really start telling you anything about me or finding out anything about you, I want you to know that I sympathize with you. Not only is it one of the most painful experiences to have backpain. Not only is it the number one excuse for employees not coming into work. But perhaps just as significantly, it is something that I suffered from for years.