In vivo experimental studies on swine intervertebral discs and in vitro tests on human discs with intradiscal administration of an O2-O3 mixture (at a concentration of 27 ^g/mL) demonstrated dehydration of the fibrillary matrix of the nucleus pulposus that disclosed the collagen mesh/ network and regressive events of fragmentation and vacuole formation. Neuroangiogenesis was sometimes present, with mild hyperplasia of the chondrocytes in the matrix periphery. Such changes are thought to be due to the decomposition of ozone accompanied by the release of free radicals that act directly on the disc matrix or indirectly via proteolytic enzymes (Figure 19.4).
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.