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In our experience, intradiscal O2-O3 treatment of selected herniated lumbar disc has revolutionized the percutaneous approach to nerve root disease by making it safer, cheaper, and easier than treatments currently in use. In addition, O2-O3 therapy does not exclude subsequent surgery, should patients fail to respond.

Oxygen-ozone treatment has the advantage of being feasible in virtually all patients with root syndromes. The contraindications of chemo-nucleolysis or nucleoaspiration, which are determined by discography, are a less critical issue with ozone.

On the basis of our results and the assessment of our failures, we recommend careful selection of patients. We avoid broad indications for treatment, thereby ensuring a high success rate.

Accurate diagnosis of the lesion and the spinal level to be treated, along with accurate technical execution under CT, are key factors in ensuring the successful outcome of percutaneous treatment for this common condition.

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