Both PV and KP seem to provide the same pain relief from vertebral compression fractures and, in experienced hands, approximately the same risk. However, kyphoplasty may provide an opportunity for restoring vertebral body height before stabilization and reduction of a fracture in the clinical setting. Because the pain relief from both procedures appears to be similar and because variables such as pulmonary function, gastrointestinal issues, and even kyphosis change in the presence of pain relief, it will be difficult to compare or distinguish the two procedures based on clinical outcomes. Any benefits of KP over PV remain to be proven, but the prospect of height restoration is compelling. A trial with patients randomly assigned to KP and PV treatment groups is needed. Separate randomized clinical trials are being considered to compare KP and PV with the conventional medical management of vertebral compression fractures.


1. Galibert P, Deramond H, Rosat P, et al. [Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty.] Neurochirurgie 1987;33(2):166-168.

2. Jensen ME, Evans AJ, Mathis JM, et al. Percutaneous polymethyl-methacrylate vertebroplasty in the treatment of osteoporotic vertebral body compression fractures: technical aspects. AJNR Am J Neuroradiol 1997; 18(10):1897-1904.

3. Gangi A, Kastler BA, Dietemann JL. Percutaneous vertebroplasty guided by a combination of CT and fluoroscopy. AJNR Am J Neuroradiol 1994; 15(1):83-86.

4. Cotten A, Dewatre F, Cortet B, et al. Percutaneous vertebroplasty for os-teolytic metastases and myeloma: effects of the percentage of lesion filling and the leakage of methyl methacrylate at clinical follow-up. Radiology 1996;200(2):525-530.

5. Mathis JM, Deramond H, Belkoff SM. Percutaneous Vertebroplasty. New York: Springer-Verlag; 2002.

6. White AA, Panjabi MM. Clinical Biomechanics of the Spine. 2nd ed. Philadelphia: Lippincott, 1990.

7. Schlaich C, Minne HW, Bruckner T, et al. Reduced pulmonary function in patients with spinal osteoporotic fractures. Osteoporos Int 1998;8(3):261-267.

8. Leech JA, Dulberg C, Kellie S, et al. Relationship of lung function to severity of osteoporosis in women. Am Rev Respir Dis 1990;141(1):68-71.

9. Silverman SL. The clinical consequences of vertebral compression fracture. Bone 1992;13(suppl 2):S27-S31.

10. Cooper C, Atkinson EJ, O'Fallon WM, et al. Incidence of clinically diagnosed vertebral fractures: a population-based study in Rochester, Minnesota, 1985-1989. J Bone Miner Res 1992;7(2):221-227.

11. Kado DM, Browner WS, Palermo L, et al. Vertebral fractures and mortality in older women: a prospective study. Study of Osteoporotic Fractures Research Group. Arch Intern Med 1999;159(11):1215-1220.

12. Wong WH, Olan WJ, Belkoff SM. Balloon kyphoplasty. In: Mathis JM, De-ramond H, Belkoff SM, eds. Percutaneous Vertebroplasty. New York: Springer-Verlag; 2002:109-124.

13. Lieberman IH, Dudeney S, Reinhardt M-K, et al. Initial outcome and efficacy of kyphoplasty in the treatment of painful osteoporotic vertebral compression fractures. Spine 2001;26(14):1631-1638.

14. Belkoff SM, Mathis JM, Fenton DC, Scribner RM, Reiley ME, Talmadge K. An ex vivo biomechanical evaluation of an inflatable bone tamp in the treatment of compression fracture. Spine 2001;26(2):151-156.

15. Belkoff SM, Mathis JM, Deramond H, Jasper LE. An ex vivo biomechani-cal evaluation of a hydroxyapatite cement for use with kyphoplasty. AJNR Am J Neuroradiol 2001;22:1212-1216.

16. Theodorou DJ, Wong WH, Duncan TD, Garfin SR, Theodorou SJ, Stoll T. Percutaneous balloon kyphoplasty: a novel technique for reducing pain and spinal deformity associated with osteoporotic vertebral compression fractures (abstr). Radiology 2000;217:511.

17. Garfin SR, Yuan HA, Reiley MA. New technologies in spine: kyphoplasty and vertebroplasty for the treatment of painful osteoporotic compression fractures. Spine 2001;26(14):1511-1515.

18. Leidig-Bruckner G, Minne HW, Schlaich C, et al. Clinical grading of spinal osteoporosis: quality of life components and spinal deformity in women with chronic low back pain and women with vertebral osteoporosis. J Bone Miner Res 1997;12(4):663-675.

19. Lyles KW, Gold DT, Shipp KM, et al. Association of osteoporotic vertebral compression fractures with impaired functional status. Am J Med 1993; 94(6):595-601.

20. Nelson DA, Kleerekoper M, Peterson EL. Reversal of vertebral deformities in osteoporosis: measurement error or "rebound"? J Bone Miner Res 1994;9(7):977-982.

21. Bai B, Jazrawi LM, Kummer FJ, et al. The use of an injectable, biodegradable calcium phosphate bone substitute for the prophylactic augmentation of osteoporotic vertebrae and the management of vertebral compression fractures. Spine 1999;24(15):1521-1526.

22. Belkoff SM, Mathis JM, Erbe EM, et al. Biomechanical evaluation of a new bone cement for use in vertebroplasty. Spine 2000;25(9):1061-1064.

23. Cunin G, Boissonnet H, Petite H, et al. Experimental vertebroplasty using osteoconductive granular material. Spine 2000;25(9):1070-1076.

24. Mermelstein LE, McLain RF, Yerby SA. Reinforcement of thoracolumbar burst fractures with calcium phosphate cement. A biomechanical study. Spine 1998;23(6):664-670.

25. Schildhauer TA, Bennett AP, Wright TM, et al. Intravertebral body reconstruction with an injectable in situ-setting carbonated apatite: biomechan-ical evaluation of a minimally invasive technique. J Orthop Res 1999;17(1): 67-72.

Was this article helpful?

0 0
Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

Get My Free Ebook

Post a comment