• Radiologic studies performed late in the disease process may show changes secondary to disuse atrophy, which may be caused by other medical conditions.

• If the sympathetically maintained pain is the result of a persistent but treatable condition, the condition needs to be treated. Treating only the signs/symptoms of CRPS without addressing the underlying condition may prove futile.

• If the patient has a diagnosed psychiatric illness (i.e., post-traumatic stress disorder, depression), this must be treated or it can adversely affect any potential improvements obtained from other treatment modalities.

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