Natural Killer Cells at the Tumors Microenvironment

Roi Gazit and Ofer Mandelboim

Abstract NK cells have the innate ability to recognize and eliminate transformed cells. However, tumors still form and progress in seemingly immune-competent individuals. The tumor microenvironment controls NK recruitment and maintenance in situ. Current understanding of NK basic biology explain in part their limitations, that might turn the anti-cancerous devotion into a tumor progression outcome. Recent progress in understanding of the evasion from NK recognition and counterattack against the killer cells are discussed, along with unresolved questions.

Keywords Natural Killer, Activating NK receptors, NK inhibition, NK suppression, tumor-ligands, tumor microenvironment.

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