Modulation of APM Components by Cytokines in the Tumor Microenvironment

The tumor microenvironment is shaped by interactions of tumor cells, stroma and infiltrating immune cells. It contains many types of cytokines produced by malignant and normal cells. The susceptibility of some APM components, including HLA class I heavy chains and 02 m, HLA-G and MICA to modulation by cytokines and epigenetic mechanisms raises the question of how their expression by tumor cells may change in the tumor microenvironment and how these changes affect the interactions of tumor cells with immune cells. Neither question has been addressed with experimental investigations in animal models or in a clinical setting. Therefore, we will address them utilizing information derived from other systems.

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