Local Tumor Growth and Spontaneous Systemic T Cell Responses in Cancer Patients A Paradox and Puzzle

Philipp Beckhove and Volker Schirrmacher

Abstract We describe and discuss the paradox situation that in many cancer patients functional antitumor memory T cells can be detected in their bone marrow which coexist with a growing tumor in the periphery. This phenomenon, known as "concomitant immunity" suggests that the tumor and its microenvironment prevent systemic antitumor immunity to become effective. Strategies of intervention at the tumor microenvironment are being discussed.

Keywords Memory T cells, bone marrow, tumor dormancy, intervention, danger signals, tumor infiltration

Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment