Contents

Foreword v

List of Contributors xi

1 Immune Effector Cells in the Tumor Microenvironment:

Their Role in Regulation of Tumor Progression 1

Theresa L. Whiteside

2 Histocompatibility Antigens, Tumor Microenvironment and Escape Mechanisms Utilized by Tumor Cells 35

Soldano Ferrone and Theresa L. Whiteside

3 Local Tumor Growth and Spontaneous Systemic T Cell

Responses in Cancer Patients: A Paradox and Puzzle 53

Philipp Beckhove and Volker Schirrmacher

4 Insights into Mechanisms of Immune Resistance in the Tumor Microenvironment through Molecular Profiling 77

Thomas F. Gajewski

5 Tumor Antigens as Modulators of the Tumor

Microenvironment 91

Katja Engelmann and Olivera J. Finn

6 Tumor Cell Resistance to Apoptosis by Infiltrating

Cytotoxic Lymphocytes 121

Benjamin Bonavida

7 The Tumor Microenvironment as a Model for Tissue-Specific Rejection 139

Silvia Selleri, Sara Deola, Cristiano Rumio, and Francesco M. Marincola

8 Functional Cytotoxicity of T Cells in the Tumor Microenvironment 157

Michal Lotem, Arthur Machlenkin, Shoshana Frankenburg, and Tamar Peretz

9 Natural Killer Cells at the Tumors Microenvironment 171

Roi Gazit and Ofer Mandelboim

10 Contribution of the Microenvironment to the Pathogenesis of EBV-Positive Hodgkin and

Nasal NK/T-cell Lymphomas 195

Eva Klein, Miki Takahara, and Lorand Levente Kis

Index 211

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