Pathogenesis of Urethral Strictures

Strictures used to stem predominantly from infectious disease (sexually transmitted diseases, tuberculosis); today most of the strictures are post-traumatic or iatrogenic. External trauma is caused by injuries such as a fracture of the pelvis. Internal traumatic lesions, mostly of the bulbar urethra, are attributable to endoscopic instruments and urethral catheters. Pathogenic factors include mucosal lesion, inflammation, and locally reduced perfusion. The pathoge-nesis of urethral strictures after catheter stems from retention of secretion with bacterial invasion along the catheter and decubital necrosis of the mucosa, which will lead to periure-thral inflammatory infiltrates and subsequent stenosis.

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