To cancer diagnostics and therapies

A goal of cancer diagnostics is to properly classify the type of cancer that a patient has contracted, often by inspecting tumor cells under the microscope. However, ge-nomic approaches have revealed that tumors that look the same under a microscope may have very different molecular bases. Let's examine how genomics can be used to address this diagnostic problem. As an example, we will consider a form of lymphoma.

Lymphomas and leukemias are cancers of the white blood cells—the cells that make up the immune system. In these diseases, certain white blood cells massively overproliferate, leading to an imbalance in immune cells and, ultimately, a failure of the immune system. One class of lymphoma is called diffuse large B-cell lymphoma (DLBCL), the most common form of non-Hodgkin's lymphoma. In the United States alone, about 25,000 new cases of DLBCL are diagnosed every year. The diagnosis is based on finding a characteristic set of symptoms and on the histology (microscopic examination of cell and tissue morphology) of affected lymph nodes (Figure 17-22). Standard chemotherapy cures about 40 percent of DLBCL patients, but other patients do not respond to this regimen. Why is there this dichotomy among the patient population? It could

17.6 Applying genomic approaches to cancer research, diagnosis, and therapies

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

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