Physiopathology of Hypogonadism

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Nonpituitary intrasellar and parasellar tumors include craniopharyngioma, Rathke's cleft cyst, epidermoid, infundibuloma, chordoma, lipoma, colloid cyst, germinoma, dermoid, teratoma, dysgerminoma, ectopic pinealoma, glioma, oligodendroglioma, ependymoma, astrocytoma, meningioma, enchondroma, metastatic tumors, and lymphoma. These masses interfere with GnRH synthesis and secretion or directly impair FSH and LH production, inducing hypogonadotropic hypogonadism. In addition, the modest hyperprolactinemia that occurs secondary to hypothalamic stalk compression could impair gonadal function (87,88).

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