Similar results have been demonstrated in men treated with cisplatin-based chemotherapy for osteosarcoma (2,33) and lung cancer (34). However, the majority of patients treated with cytotoxic chemotherapy for leukemia do not have persistent gonadal dysfunction. Wallace et al. (35) found long-term germinal epithelial dysfunction in only 6 out of 36 (17%) patients treated during childhood for acute lympho-cytic leukemia, although the follow-up period in this study was considerable, and the majority of patients had evidence of germinal epithelial damage on testicular biopsy immediately after chemotherapy (which included cyclophosphamide and cytosine arabinoside), a median time of 10.7 yr earlier.
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Among the evils which a vitiated appetite has fastened upon mankind, those that arise from the use of Tobacco hold a prominent place, and call loudly for reform. We pity the poor Chinese, who stupifies body and mind with opium, and the wretched Hindoo, who is under a similar slavery to his favorite plant, the Betel but we present the humiliating spectacle of an enlightened and christian nation, wasting annually more than twenty-five millions of dollars, and destroying the health and the lives of thousands, by a practice not at all less degrading than that of the Chinese or Hindoo.