Other Associations of Cancer and Hypogonadism

Cryptorchidism is associated with spermatogenesis impairment and an increased risk of neoplastic change in the testes. Tumors arising in the region of the pituitary and hypothalamus or their treatment may result in hypopituitarism and consequent hypogonadism. Hormonally active tumors elsewhere may also inhibit hypothalamic-pituitary function. Ectopic adrenocorticotropic hormone (ACTH) secretion, most commonly from lung tumors, may cause secondary hypogonadism. Androgen-secreting tumors may suppress gonadotrophin secretion, thereby causing oligospermia or azoospermia. However, with the exception of cryptorchidism, hypogonadism would be an unusual presentation for these conditions.

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