Crystalline testosterone in pellets had been inserted into the abdominal subcutaneous fat for androgen replacement in hypogonadal men. In Europe and Australia, where testosterone pellets are available in 100- and 200-mg doses, they are frequently used to treat hypogonadal men (100,101). Four 200-mg implants maintain testosterone levels for 16 to 20 wk. Insertion of the pellets requires a minor surgical procedure under local anesthesia. Extrusion of the testosterone pellets is observed in approx 8 to 11% of subjects (102), although our experience with insertion by a skilled operative is much lower. This method has not been widely used and is not routinely offered by physicians as androgen-replacement modality in the United States.

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