Hypogonadotropic Hypogonadism

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Hypogonadotropic hypogonadism is a clinical syndrome resulting from a disorder of the pituitary gland, or hypothalamus, or from systemic factors that suppress GnRH production. Hypogonadotropic hypogonadism can be congenital, i.e., Kallmann syndrome, or acquired, which most often results from a pituitary tumor. Head trauma, central nervous system (CNS) infections, hemochromatosis, radiotherapy, and vascular disorders can also lead to pituitary insufficiency (4). Hypogonadotropic hypogonadism can occur together with other endocrine deficiencies or can be selective.

Underlying Cause secondary hypo gonad is m/

hypogonadotropic hypogonadism primary hypogonadism/ hypergonadotropic hypogonadism

Klinefelter syndrome

Kallmann Syndrome

Fig. 1. Treatment of hypogonadism according to pathogenesis.

Kallmann Syndrome Pituitary Gland

Fig. 2. Bitesticular volume (—) and sperm concentration (---) in men with hypogonadotropic hypogonadism during continuation treatment with human chorionic gonadotropin (hCG) alone expressed as a percentage of the final value during hCG/human menopausal gonadotropin treatment. (Data modified from ref. 9.)

Fig. 2. Bitesticular volume (—) and sperm concentration (---) in men with hypogonadotropic hypogonadism during continuation treatment with human chorionic gonadotropin (hCG) alone expressed as a percentage of the final value during hCG/human menopausal gonadotropin treatment. (Data modified from ref. 9.)

Treatment goals include the maintenance of androgen levels in the normal adult male range to allow full virilization and prevention of androgen deficiency symptoms. Furthermore, the initiation or restoration of spermatogenesis is often an integral part of the treatment plan.

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