Rivkees and Crawford (5) published a meta-analysis of 30 studies that examined gonadal function after various chemotherapy regimens, which included 116 men who had been treated with cyclophosphamide alone. Gonadal function and/or histology were assessed by several different methods; semen analysis, basal LH and follicle-stimulating hormone (FSH) levels, and testicular biopsy were the most commonly used. Of the 116

patients, 52 (45%) had evidence of testicular dysfunction after treatment. The finding of gonadal dysfunction correlated with the total dose of cyclophosphamide, occurring in more than 80% of postpubertal patients who received more than 300 mg/kg.

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