Conversion of Dehydroepiandrosterone to Testosterone

The microsomal enzyme 17P-hydroxysteroid dehydrogenase (17P-HSD) catalyzes the interconversion of dehydroepiandrosterone and androstenediol, or androstenedione and testosterone. The 17P-dehydrogenase reaction is reversible, in contrast to the previous reactions in testosterone biosynthesis (60). Following the A5 pathway in humans, the C19 product, dehydroepiandrosterone, is converted to androstenediol by 17P-HSD, and then androstenediol is converted to testosterone by 3P-HSD. In the A4 pathway occurring in rodents, 17P-HSD uses androstenedione as substrate to produce testosterone (61). Testosterone is the principle steroid end product secreted by adult Leydig cells, but it can be further metabolized to 17P-estradiol (E2) and dehydrotestosterone (DHT) before secretion.

Was this article helpful?

0 0
Vanish Man Boobs

Vanish Man Boobs

Say goodbye to embarrassing man boobs forever. Thats right. Im going to share all of the research I collected and the cures I found with you. It is entirely possible to cure your man boobs forever without the use of drugs or surgery. Im going to show you how.

Get My Free Ebook


Post a comment