Preface v

Contributors ix

1 Neuroendocrine Control of Testicular Function

Stephen J. Winters and Alan C. Dalkin 1

2 Leydig Cell Function in Man

Qiang Dong and Matthew P. Hardy 23

3 Spermatogenesis and Its Regulation in Higher Primates

Gary R. Marshall 45

4 Normal and Delayed Puberty

Leo Dunkel 63

5 Congenital Hypogonadotropic Hypogonadism: Clinical Features and Pathophysiology William F. Crowley and Nelly Pitteloud 81

6 Male Hypogonadism Resulting From Mutations in the Genes for the Gonadotropin Subunits and Their Receptors Ilpo T. Huhtaniemi 101

7 Hypogonadism in Males With Congenital Adrenal Hyperplasia Barto J. Otten, Nike M. M. L. Stikkelbroeck, and Ad R. M. M. Hermus 125

8 Male Hypogonadism Resulting From Disorders of the Pituitary and Suprasellar Region

Annamaria Colao, Giovanni Vitale, Michele De Rosa, and Gaetano Lombardi 139

9 Klinefelter's Syndrome

John K. Amory and William J. Bremner 159

10 Cryptorchidism

Peter A. Lee, Barry A. Kogan, and Michael T. Coughlin 171

11 Hypogonadism in Men With HIV-AIDS

Shalender Bhasin 207

12 Hypogonadism in Men With Chronic Renal Failure

Peter Y. Liu and David J. Handelsman 227

13 Male Hypogonadism Resulting From Cancer and Cancer Treatments Simon J. Howell and Stephen M. Shalet 247

14 An Ensemble Perspective of Aging-Related Hypoandrogenemia in Men

Johannes D. Veldhuis, Ali Iranmanesh, and Daniel Keenan 263

15 Environmental Causes of Testicular Dysfunction

Richard M. Sharpe 287

16 Exercise and Male Hypogonadism: Testosterone, the Hypothalamic-

Pituitary-Testicular Axis, and Physical Exercise Anthony C. Hackney and Jennifer Dobridge 305

17 Testosterone, SHBG, and the Metabolic Cardiovascular


Joseph M. Zmuda and Stephen J. Winters 331

18 Androgen Replacement Therapy in Hypogonadal Men

Christina Wang and Ronald S. Swerdloff 353

19 Stimulation of Spermatogenesis in Hypogonadotropic Men

Marion Depenbusch and Eberhard Nieschlag 371

Index 387

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