Studies of changes in cognitive function in hypogonadal younger men are lacking except for uncontrolled studies in men with Klinefelter syndrome in whom testosterone replacement improved verbal skills (27-29). In younger eugonadal men rendered hypogonadal by exogenous administration of a progestin, verbal memory was reduced, which was corrected when testosterone was added to the progestin administration (30). In older hypogonadal men, several well-controlled studies with limited numbers of subjects reported better performances on spatial ability, and, in some studies, verbal memory was also improved after androgen replacement (31-35).
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