Cognitive Function

Studies of changes in cognitive function in hypogonadal younger men are lacking except for uncontrolled studies in men with Klinefelter syndrome in whom testosterone replacement improved verbal skills (27-29). In younger eugonadal men rendered hypogonadal by exogenous administration of a progestin, verbal memory was reduced, which was corrected when testosterone was added to the progestin administration (30). In older hypogonadal men, several well-controlled studies with limited numbers of subjects reported better performances on spatial ability, and, in some studies, verbal memory was also improved after androgen replacement (31-35).

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