Of Mice And Rats

chapter in terms of applying rodent behavioral paradigms in mice is based on their research (11-14).

It is also important to note that while the behaviors we are discussing are exhibited by both rats and mice, there are significant interspecies differences in learning behavior. In general, these differences can be summed up by saying that rats are a lot smarter than mice. In fact, in the early days, there was some discussion of whether mice could even learn to perform some of the standard rat behavioral paradigms, although fortunately this concern was unfounded.

Finally, it is important to point out that, in addition to interspecies differences, there are appreciable interstrain differences in learning behavior. Learning in outbred

strains of rats and mice is typically much more robust than that in inbred strains. Additionally, different inbred strains of rats and mice have different, specific deficits that affect their learning and memory. Many of these differences are described by Crawley et al. (11).

in rodents has also been identified. While taste learning has not been nearly as extensively studied as the spatial learning tasks described previously, these types of paradigms hold great promise for future use. They represent one of the most tractable experimental models for measuring cortically dependent learning in rodents.

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