Workers in the cerebellum might state that LTP does not equal memory because LTD equals memory. Specifically, LTD of synaptic connections in the cerebellar cortex has been demonstrated to play a role in two important forms of learned behavior: adaptation of the vestibulo-ocular reflex (VOR) and eye-blink conditioning (reviewed in references 10 and 58).
As we discussed in Chapter 2, classical conditioning of the eye-blink response in rabbits uses delivery of a neutral stimulus such as a tone paired with a mild aversive stimulus such as an airpuff delivered to the surface of the eye (Panel A). With repeated pairings, animals learn that the tone predicts the air-puff, and they will learn to "blink" when the tone is delivered by itself; a learned protective response involving co-opting a reflex pathway. Eye-blink conditioning sounds simple but is actually fairly complex. For example, the "blink" is really more than a blink; it is an elaborate programmed motor response involving a number of muscle groups that cause eyeball retraction and closure of the eyelid. The animals also can learn precisely the temporal relationship between tone and air-puff. They automatically adjust their "blink" to slightly precede when the air-puff would be
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