Analgesics

The most consumed drugs are analgesics. Basically there are two main categories of analgesics, namely nonsteroidal antiinflammatory drugs (NSAIDs) and opioids. Many active ingredients are in the market in several hundreds of brand name. NSAIDs are used to treat not only pain but also other medical problems as well, including fever, inflammation, and prevention of thrombosis. According to their chemical structure, NSAIDs can be classified into different classes such as anthranilic acid,...

Diagnostic oncoproteomics based on Selditofms

Oncoproteomics is the systematic application of proteomic technologies to oncology research 60 . Diagnostic proteomics concentrates on differential display comparisons of protein (peptide) concentrations in plasma or urine in health and disease with the following objectives (i) early, rapid, and reliable diagnosis of cancer for timely therapeutic intervention based on identified specific markers (ii) early diagnosis of relapse (iii) early diagnosis for risk assessment to aid prevention....

References

Wild, G.C. and Benzel, E.C., Central nervous system cell types. In Essentials of Neurochemistry. Jones and Bartlett, Boston, 1994, pp. 3-15 Chapter 1, ISBN 0-86720-862-7 . 2. Wild, G.C. and Benzel, E.C., The synapse. In Essentials of Neurochemistry. Jones and Bartlett, Boston, 1994, pp. 33-43 Chapter 3, ISBN 0-86720-862-7 . 3. Shah, A.J., Crespi, F. and Heidbreder, C., Amino acid neurotransmitters separation approaches and diagnostic value. J. Chromatogr. B, 781, 151-163 2002 . 4. Cheng,...

Miscellaneous drug classes

There are many categories of drugs that are used in clinical practice. In these cases, TDM is usually not required. However, measuring drug concentrations in blood or other body fluids e.g., urine might contribute to developing optimal therapeutic dosing strategies, predicting accumulation, and measuring elimination. MS can also be used to differentiate between natural and synthetic molecules within the body, such as steroids or insulin, to detect doping. In Table 8, results on miscellaneous...

Cardiovascular drugs

Cardiovascular drugs are the common name of compounds used to treat different heart disorders such as congestive heart failure, angina, or arrhythmia or diseases of the vascular system e.g., hypertension . Heart failure can be acute sudden left-ventricular insufficiency and as a consequence lung failure without hypertrophy of heart muscle , compensatory no lung failure but hypertrophy of heart muscle , or exhaustive no more compensation of the heart muscle even though there is hypertrophy ....

Anticancer agents

TDM in oncology was first applied for the measurement of methotrexate plasma concentrations following high-dose treatment, then it was gradually extended to the dose modifications in case of liver or kidney failure 41 . There are arguments in favor of and against TDM in antineoplastic treatment. Anticancer agents are usually applied in maximal tolerable doses even though their pharmacokinetics are variable thus, TDM could improve safety by preventing overdose and efficacy providing maximum...

Inborn errors of metabolism

Urine Oligosaccharides Gamt

IEM are individually rare but may be collectively as frequent as 1 affected individual in 500 newborn infants. They encompass many different single-gene disorders affecting many aspects of cellular metabolism 10 . A significant portion relates to disorders of fatty acid, protein, and carbohydrate metabolism 10 . Analysis of IEM relies on semiquantitative or quantitative measurement of characteristic small molecules in different body fluids including blood, plasma, cerebral spinal fluid, and...

Fab 460

FAB see fast-atom bombardment Fabry disease 239 factors 144 familial adenomatous polyposis FAP 394 FAP see familial adenomatous polyposis fast-atom bombardment FAB 98, 110, 111, 342 fatty acid oxidation defects 257 fatty acids 45 Fc region 333 FD see field desorption fenofibric acid 275 ferritin light chain FLC 497 FIA see flow-injection analysis FID see flame ionization detection field desorption FD 99 FIGLU see formimino glutamic acid filter membranes 42 filtration 42 fingerprint signature...

Contents

Motivation and Essentials 1 Basics of Analytical Chemistry and Mass Spectrometry for 2. Terms and Definitions 9 3. The Analytical Procedure 11 4. A Case Study Analysis of Plasma Sterol Profile 14 5. Mass Spectrometry 16 Reference 18 Ethical, Legal, Safety, and Scientific Aspects of Medical Research 19 4. Handling Biological Materials 25 5. Clinical Trials and Protocols 28 6. Administrative Procedures 33 References 34 Part II. Tools of the Trade 35 Chapter 4 Gyorgy Vas, Kornel Nagy, and...