Diagnostic oncoproteomics based on Selditofms

Oncoproteomics is the systematic application of proteomic technologies to oncology research 60 . Diagnostic proteomics concentrates on differential display comparisons of protein (peptide) concentrations in plasma or urine in health and disease with the following objectives (i) early, rapid, and reliable diagnosis of cancer for timely therapeutic intervention based on identified specific markers (ii) early diagnosis of relapse (iii) early diagnosis for risk assessment to aid prevention....

References

Wild, G.C. and Benzel, E.C., Central nervous system cell types. In Essentials of Neurochemistry. Jones and Bartlett, Boston, 1994, pp. 3-15 Chapter 1, ISBN 0-86720-862-7 . 2. Wild, G.C. and Benzel, E.C., The synapse. In Essentials of Neurochemistry. Jones and Bartlett, Boston, 1994, pp. 33-43 Chapter 3, ISBN 0-86720-862-7 . 3. Shah, A.J., Crespi, F. and Heidbreder, C., Amino acid neurotransmitters separation approaches and diagnostic value. J. Chromatogr. B, 781, 151-163 2002 . 4. Cheng,...

Drugs acting on the central nervous system CNS

Epilepsy can be explained as communication disorder among nerve cells. The disintegration of the balance of the excitatory and inhibitory stimuli leads to the predominance of excitatory impulses thus, epileptic fit could occur. In the brain the most important excitatory neurotransmitter is glutamate, while the major inhibitory neurotransmitter is GABA. Thus, increasing GABA or decreasing glutamate can suppress the incidence of fits. TDM is indicated in the treatment of epilepsy since the...

Miscellaneous drug classes

There are many categories of drugs that are used in clinical practice. In these cases, TDM is usually not required. However, measuring drug concentrations in blood or other body fluids e.g., urine might contribute to developing optimal therapeutic dosing strategies, predicting accumulation, and measuring elimination. MS can also be used to differentiate between natural and synthetic molecules within the body, such as steroids or insulin, to detect doping. In Table 8, results on miscellaneous...

Cardiovascular drugs

Cardiovascular drugs are the common name of compounds used to treat different heart disorders such as congestive heart failure, angina, or arrhythmia or diseases of the vascular system e.g., hypertension . Heart failure can be acute sudden left-ventricular insufficiency and as a consequence lung failure without hypertrophy of heart muscle , compensatory no lung failure but hypertrophy of heart muscle , or exhaustive no more compensation of the heart muscle even though there is hypertrophy ....

Anticancer agents

TDM in oncology was first applied for the measurement of methotrexate plasma concentrations following high-dose treatment, then it was gradually extended to the dose modifications in case of liver or kidney failure 41 . There are arguments in favor of and against TDM in antineoplastic treatment. Anticancer agents are usually applied in maximal tolerable doses even though their pharmacokinetics are variable thus, TDM could improve safety by preventing overdose and efficacy providing maximum...

Inborn errors of metabolism

Urine Oligosaccharides Gamt

IEM are individually rare but may be collectively as frequent as 1 affected individual in 500 newborn infants. They encompass many different single-gene disorders affecting many aspects of cellular metabolism 10 . A significant portion relates to disorders of fatty acid, protein, and carbohydrate metabolism 10 . Analysis of IEM relies on semiquantitative or quantitative measurement of characteristic small molecules in different body fluids including blood, plasma, cerebral spinal fluid, and...

Fab 460

FAB see fast-atom bombardment Fabry disease 239 factors 144 familial adenomatous polyposis FAP 394 FAP see familial adenomatous polyposis fast-atom bombardment FAB 98, 110, 111, 342 fatty acid oxidation defects 257 fatty acids 45 Fc region 333 FD see field desorption fenofibric acid 275 ferritin light chain FLC 497 FIA see flow-injection analysis FID see flame ionization detection field desorption FD 99 FIGLU see formimino glutamic acid filter membranes 42 filtration 42 fingerprint signature...