Diagnostic oncoproteomics based on Selditofms

Oncoproteomics is the systematic application of proteomic technologies to oncology research 60 . Diagnostic proteomics concentrates on differential display comparisons of protein (peptide) concentrations in plasma or urine in health and disease with the following objectives (i) early, rapid, and reliable diagnosis of cancer for timely therapeutic intervention based on identified specific markers (ii) early diagnosis of relapse (iii) early diagnosis for risk assessment to aid prevention....

Mass spectrometry instrumentation and techniques

Department of Chemistry, University of Arizona, Tucson, AZ, USA 2. General questions about mass measurement and mass spectrometry 96 3. Separation techniques gas chromatography GC , and high-performance liquid chromatography HPLC 100 4.1. Electron impact EI ionization 104 4.2. Chemical ionization CI 108 4.3. Fast-atom bombardment FAB and liquid secondary ion mass spectrometry LSIMS 110 4.4. Electrospray ionization ESI 111 4.5. Atmospheric pressure chemical ionization APCI 115 4.6....

Introduction Of Abortification Foods

Allergies are unpleasant ailments and actually, in some cases, acute life-threatening diseases. The term allergy from Greek alios other and ergon reaction was first mentioned 100 years ago by an Austrian pediatrician named Clemens von Pirquet in 1906 1 . He noticed that some of his vaccinated patients had more severe reactions to ongoing treatment and followed this to be a response to outside elicitors. Since this observation hypersensitivities were thought to result from unpredictable actions...

Miscellaneous drug classes

There are many categories of drugs that are used in clinical practice. In these cases, TDM is usually not required. However, measuring drug concentrations in blood or other body fluids e.g., urine might contribute to developing optimal therapeutic dosing strategies, predicting accumulation, and measuring elimination. MS can also be used to differentiate between natural and synthetic molecules within the body, such as steroids or insulin, to detect doping. In Table 8, results on miscellaneous...

Cardiovascular drugs

Cardiovascular drugs are the common name of compounds used to treat different heart disorders such as congestive heart failure, angina, or arrhythmia or diseases of the vascular system e.g., hypertension . Heart failure can be acute sudden left-ventricular insufficiency and as a consequence lung failure without hypertrophy of heart muscle , compensatory no lung failure but hypertrophy of heart muscle , or exhaustive no more compensation of the heart muscle even though there is hypertrophy ....

Anticancer agents

TDM in oncology was first applied for the measurement of methotrexate plasma concentrations following high-dose treatment, then it was gradually extended to the dose modifications in case of liver or kidney failure 41 . There are arguments in favor of and against TDM in antineoplastic treatment. Anticancer agents are usually applied in maximal tolerable doses even though their pharmacokinetics are variable thus, TDM could improve safety by preventing overdose and efficacy providing maximum...

References

Chace, D.H., Kalas, T.A. and Naylor, W.N., Use of tandem mass spectrometry for multianalyte screening of dried blood specimens from newborns. Clin. Chem., 49, 1797-1817 2003 . 2. Bennett, M.J. and Rinaldo, P., The metabolic autopsy comes of age. Clin. Chem., 47, 1145-1146 2001 . 3. Guthrie, R. and Susi, A., A simple phenylalanine method for detecting phenylketonuria in large populations of newborn infants. Pediatrics, 32, 338-343 1963 . 4. Chace, D.H., Millington, D.S., Terada, N., Kahler,...