The Liver Secretes Bile Pigments

The major pigment present in bile is the orange compound bilirubin, an end-product of hemoglobin degradation in the monocyte-macrophage system in the spleen, bone marrow, and liver (Fig. 27.17). Hemoglobin is first converted to biliverdin with the release of iron and globin. Biliverdin is then converted into bilirubin, which is transported in blood bound to albumin. The liver removes bilirubin from the circulation rapidly and conjugates it with glucuronic acid. The glucuronide is secreted into the bile canaliculi through an active carrier-mediated process.

In the small intestine, bilirubin glucuronide is poorly ab-

Stercobilin Urobilinogen
The metabolism and excretion of bile pigment (bilirubin).

sorbed. In the colon, however, bacteria deconjugate it, and part of the bilirubin released is converted to the highly soluble, colorless compound called urobilinogen. Urobilinogen can be oxidized in the intestine to stercobilin or absorbed by the small intestine. It is excreted in either urine or bile. Ster-cobilin is responsible for the brown color of the stool.

point that it cannot be solubilized, it starts to crystallize, forming gallstones. Eventually, calcium deposits form in the stones, increasing their opacity and making them easily detectable on X-ray images of the gallbladder.

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Responses

  • jay
    How the liver producesbile pigments?
    3 years ago
  • ALIISA
    Which bile pigments are excreted by liver?
    3 years ago
  • Hazel
    Where do they bile pigment excreted by the liver come from?
    2 years ago
  • Robur
    What does the liver degrade and secrete as pigments in the bile?
    2 years ago
  • VIOLANDA
    How to treatment bile pigment?
    2 years ago
  • jessika
    Which par of the body remove Bile pigment ?
    2 years ago
  • Kerttu
    Why do we need to remove bile pigments?
    2 years ago
  • tommy
    What are the bilepigment of the liver?
    2 years ago
  • kaelyn
    How globin is converted into bile juice?
    2 years ago
  • Lloyd
    Are bile pigments the excretory products ?
    1 year ago
  • MIKKO
    What Is The Name Of The Bile Pigment Secreted From The Liver?
    1 year ago
  • viola
    Which body organ helps in removing bile pigment?
    1 year ago
  • Trahand
    Why are bile pigments considered as excretory products?
    1 year ago
  • jenice
    WHY ARE BILE PIGMENTS CONSIDERED AS AN EXCRETORY PRODUCT?
    1 year ago
  • maxima
    Why bile pigment is considered excretory products?
    1 year ago
  • manlio
    Why are the bile pigment considered as an excretory product?
    1 year ago
  • ERIC SMITH
    How are bile pigments excreted from the body?
    8 months ago
  • sophia
    How to treat bile pigment?
    4 months ago

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