The Insulin Glucagon Ratio Determines Metabolic Status

In most instances, insulin and glucagon produce opposing effects. Therefore, the net physiological response is determined by the relative levels of both hormones in the blood plasma, the insulin-glucagon ratio (I/G ratio).

I/G Ratio in the Fed and Fasting States. The I/G ratio may vary 100-fold or more because the plasma concentration of each hormone can vary considerably in different nutritional states. In the fed state, the molar I/G ratio is approximately 30. After an overnight fast, it may fall to about 2, and with prolonged fasting, it may fall to as low as 0.5.

Inappropriate I/G Ratios in Diabetes. A good example of the profound influence of the I/G ratio on metabolic status is in insulin-deficient diabetes. Insulin levels are low, so pathways that insulin stimulates operate at a reduced level.

However, insulin is also necessary for alpha cells to sense blood glucose appropriately,- in the absence of insulin, the secretion of glucagon is inappropriately elevated. The result is an imbalance in the I/G ratio and an accentuation of glucagon effects well above what would be seen in normal states of low insulin, such as in fasting.

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

Get My Free Ebook

Post a comment