[proteinate ] [H-protein]
If an acid or a base is added to such a complex mixture of buffers, all buffers take part in buffering and shift from one form (base or acid) to the other. The relative importance of each buffer depends on its amount, pK, and availability.
The isohydric principle underscores the fact that it is the concentration ratio for any buffer pair, together with its pK, that sets the pH. We can focus on the concentration ratio for one buffer pair and all other buffers will automatically adjust their ratios according to the pH and their pK values.
The rest of this chapter emphasizes the role of the HCO3~/CO2 buffer pair in setting the blood pH. Other buffers, however, are present and active. The HCO3~/CO2 system is emphasized because physiological mechanisms (lungs and kidneys) regulate pH by acting on components of this buffer system.
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.