Figure 27.7 depicts the changes in the electrolyte composition of gastric juice at different secretion rates. At a low secretion rate, gastric juice contains high concentrations of Na+ and Cl_ and low concentrations of K+ and H + . When the rate of secretion increases, the concentration of Na+ decreases while that of H+ increases significantly. Also coupled with this increase in gastric secretion is an increase in Cl" concentration. To understand the changes in electrolyte composition of gastric juice at different secretion rates, it is important to remember that gastric juice is derived from the secretions of two major sources: parietal cells and nonparietal cells. Secretion from nonparietal cells is probably constant; therefore, it is parietal secretion (HCl secretion) that contributes mainly to the changes in electrolyte composition with higher secretion rates.
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