Problems to Solve

1. A newborn has unilateral aphakia (absent lens). What is the embryological origin of this defect?

2. In taking a history of a young woman in her 10th week of gestation you become concerned that she may have contracted rubella sometime during the fourth to eighth weeks of her pregnancy. What types of defects might be produced in her offspring?

3. Physical examination of a newborn reveals clefts in the lower portion of the iris bilaterally. What is the embryological basis for this defect? What other structures might be involved?

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