Dermis

Severe Ichthyosis
Figure 18.2 Ichthyosis in a harlequin fetus with massive thickening of the keratin layer, which cracks to form fissures between thickened plaques.

CLINICAL CORRELATES Keratinization of the skin

Ichthyosis, excessive keratinization of the skin, is characteristic of a group of hereditary disorders that are usually inherited as an autosomal recessive trait but may also be X-linked. In severe cases, ichthyosis may result in a grotesque appearance, as in the case of a harlequin fetus (Fig. 18.2).

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