The blastocyst is more deeply embedded in the endometrium, and the penetration defect in the surface epithelium is closed by a fibrin coagulum (Fig. 3.3). The trophoblast shows considerable progress in development, particularly at the embryonic pole, where vacuoles appear in the syncytium. When these vacuoles fuse, they form large lacunae, and this phase of trophoblast development is thus known as the lacunar stage (Fig. 3.3).

At the abembryonic pole, meanwhile, flattened cells probably originating from the hypoblast form a thin membrane, the exocoelomic (Heuser's) membrane, that lines the inner surface of the cytotrophoblast (Fig. 3.3). This membrane, together with the hypoblast, forms the lining of the exocoelomic cavity, or primitive yolk sac.

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