Primordial Germ Cells (PGCs) and Teratomas
Teratomas are tumors of disputed origin that often contain a variety of tissues, such as bone, hair, muscle, gut epithelia, and others. It is thought that these tumors arise from a pluripotent stem cell that can differentiate into any of the three germ layers or their derivatives.
Some evidence suggests that PGCs that have strayed from their normal migratory paths could be responsible for some of these tumors. Another source is epiblast cells migrating through the primitive streak during gastrulation (see page 80).
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