Subsets of ankylosing spondylitis

1. Juvenile ankylosing spondylitis. In childhood, AS usually presents in older boys as an asymmetric oligoarticular arthritis of the lower extremities, often predating back symptoms. Heel pain is a common complaint. However, with time, the child acquires more typical features of adult AS. Almost all children affected are positive for HLA-B27.

2. Asymptomatic sacroiliitis. Among asymptomatic HLA-B27-positive relatives of probands with AS and among random asymptomatic persons who are HLA-B27-positive, 20% may be found to have radiographic sacroiliitis. Also, about one-fourth of HLA-B27-positive patients with acute anterior uveitis will have subtle clinical or radiographic evidence of sacroiliitis. Some of these patients may progress to overt clinical disease.

Was this article helpful?

0 0

Post a comment