CThe large proximal synovial joints hips knees shoulders

2. Extraskeletal sites of inflammation and post-inflammatory fibrous tissue include the uveal tract, aortic root wall, apical lung parenchyma, and heart valves.

3. Pathologic findings. Fibrocartilage is the primary site of inflammation in articular tissues. Other areas of inflammation include subchondral bone (osteitis), the annulus fibrosis of intervertebral disks, perispinal ligaments, periarticular ligamentous-bony junctions (enthesitis), periosteum (periostitis), and occasionally synovial membranes (synovitis).

In all these tissues, the initial cellular inflammatory changes are followed by fibrosis and often ossification, which lead ultimately to bony ankylosis.

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