Deficiency of enzymes in the glycolytic pathway

Muscle phosphorylase deficiency McArdle disease . This inherited deficiency of skeletal muscle phosphorylase is more common than acid maltase deficiency or PFK deficiency 60 cases have been reported. The female-to-male ratio is 1 4. Childhood symptoms of fatigue are usually overlooked. A characteristic pattern of exercise-induced muscle pains, stiffness, and weakness, which resolves with rest, occurs after puberty. Prolonged exercise results in severe cramps of the exerted muscles....

Lupus erythematosus

The lupus band test LBT demonstrates deposits of immunoglobulin and complement at the dermal-epidermal junction by direct immunofluorescent staining of the skin. Biopsy of cutaneous lesions in DLE or systemic lupus erythematosus SLE yields a positive LBT in about 90 of patients. Clinically normal skin of patients with DLE demonstrates a negative LBT. The LBT in clinically normal skin of patients with SLE varies with sun exposure. Approximately 50 of patients with SLE have a positive LBT in...