End

Figure 4.1-2 illustrates the response of the system to a narrow (100 |is) pulse of presynaptic ACh release; 300 |is is allowed for the diffusion time. Note that the modeled psp is proportional to x(t); x(t) differs from vm(t) by a scale factor.

FIGURE 4.1-2 Results of a nonlinear chemical kinetic model for epsp generation. The Simnon program, nicochan.t, was used. See text for details. Vertical scale, arbitrary units; horizontal scale, ms. Parameters: Kj = 10; K2 = K3 = K4 = 1. Trace 1, y (ACh conc. in cleft); 2, x (2ACh+ion channel complex conc.); 3, a(t).

FIGURE 4.1-2 Results of a nonlinear chemical kinetic model for epsp generation. The Simnon program, nicochan.t, was used. See text for details. Vertical scale, arbitrary units; horizontal scale, ms. Parameters: Kj = 10; K2 = K3 = K4 = 1. Trace 1, y (ACh conc. in cleft); 2, x (2ACh+ion channel complex conc.); 3, a(t).

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