Anterior Pituitary Hormones and Their Control Substances

Anterior Pituitary Hormones

Thyrotropin Prolactin

Gonadotropin, leutinizing hormone, follicle-stimulating hormone Adrenocorticotropin (ACTH), p-lipotropin Growth hormone (GH)

Melanocyte-stimulating hormone (MSH), p -endorphin

Controlling Hormones

Thyrotropin-releasing hormone (TRH) Prolactin-releasing factor (PRF), prolactin release-

inhibiting hormone (PIH), dopamine Gonadotropin-releasing factor (GnRF)

Corticotropin-releasing hormone (CRH) Growth hormone-releasing hormone (GHRH), GH release-inhibiting hormone (GIH, somatostatin) MSH-releasing factor (MRF), MSH-release inhibiting factor (MIF)

The amino acid sequences are known for the peptide control hormones, GHRH, CRH, somatostatin, LHRH, and TRH (Kandel et al., 1991). The substances affecting the release of the anterior pituitary hormones are carried to the neurosecretory cells by blood in the local, hypophyseal-portal vessels running between capillary beds in the median eminence of the pituitary and the cells.

To discuss the target organs of the anterior pituitary hormones and their functions is too far afield from the subject here. The interested reader should refer to Chapter 75 in Guyton (1991) or Chapter 6 in Northrop (1999).

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