The Red Wine Diet
When linezolid is used with antiplatelet drugs such as aspirin or the NSAIDs (see Chap. 18) there is an increased risk of bleeding and thrombocytopenia. When administered with the MAOIs (see Chap. 31) the effects of the MAOIs are decreased. There is a risk of severe hypertension if linezolid is combined with large amounts of food containing tyramine (eg, aged cheese, caffeinated beverages, yogurt, chocolate, red wine, beer, pepperoni).
Histamine or HRF is found in high concentrations in Parmesan or Roquefort cheese, red wine, and strawberries. Other active substances that are implicated in allergic reactions are also found in foods. Serotonin, a small molecule that dilates capillaries, increases capillary permeability, and contracts smooth muscle, is found in high concentrations in bananas, pineapples, plantain, and avocados.
Red wine strongly inhibits ET-1 synthesis (125) phenolic acids in wine prevent LDL oxidation in the arterial wall (126), increases eNOS expression in HUVEC (127), inhibits PDGF-P receptor activation (128), and inhibits the proliferation and DNA synthesis in cultured rat VSMC (129). However, alcohol is a complementary component of phenolics in the benefits of red wine in hypercholesterolemic golden Syrian hamsters (130).
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