Sgaldi 116

silicon 289 ff.

silver staining 50

sinapic acid 286

single ion monitoring (SIM) 26, 201, 204 single nucleotide polymorphism (SNP) 54

size exclusion

see also reversed phase chromatography

- membrane 164 SKF 83566 258ff., 273 f. SNAP 5114 273 f.

sodium dodecyl sulfate polyacrylamide gel

(SDS-PAGE) 51, 366 solid phase extraction (SPE) 43, 260ff. solvent 66

sorbitol dehydrogenase 228 spectra interpretation 48 f. spermicides 292

spin column 65 ff., 73 f., 83 f., 89 ff., 108ff., 159

spiperone 258, 261 ff. staircase method 224 f. staurosporine 76 f., 80, 133, 137 ff., 148 streptavidin 202 ff. Streptococcus pneumoniae 163 stroke 313

strong cation exchange column (SCX) 51 structure activity relationship (SAR) 158,

171, 311, 331 ff. structure elucidation 11, 45 succinic acid 286 sulfamoyl fragment 317 sulpiride 258 ff. SUPREX 123, 358ff.

- definition 161

surface enhanced laser desorption/ionization

(SELDI) 23, 49 surface plasmon resonance (SPR) 122, 160,

219, 239, 253 survey scan 46 synaptic cleft 269

system monitoring compounds (SMC) 187, 191 f., 197 f.

t tamoxifen 229

tandem chromatographic methods 114 tandem mass spectrometry 11, 409

- MALDI-TOF/TOF 51 Tardive dyskinesia 269 target 248ff., 268ff., 313

- ligand interactions 63 ff., 254 tethering 305 ff. tetra-O-galloyl-b-D-glucose 243 therapeutics 393

therapeutic monitoring 54 thermodynamic sensors 379

thermospray (TSP) 4 Thermotaga maritima 384 thioflavin T 197 thiol 306, 313 thiophene sulfone 314 f. thiostrepton 324 ff.

thymidine monophosphate (dTMP) 310 thymidylate synthase (TS) 310 ff. tiagabine 269, 273 f. time delayed fragmentation (TDF) 32 time of flight (TOF) 5, 22, 30, 33 ff., 47, 69 ff., 90, 98, 195 ff., 203 ff., 243, 290, 307 f., 343, 347, 364 - TOF-TOF 36, 57 titration 108ff., 131 ff., 341, 342 f., 348ff. N-tosyl-D-proline 310 ff. total ion current (TIC) 56, 190ff., 309 toxicology 41

transferrin-binding protein B (TbpB) 240

transmission 24, 33 2,4,6-trichloro-1,3,5-triazine see cyanuric chloride trifluoromethylene ketone (TFMK) 99 ff.

trifluperazine 258 ff.

trimethoprim 137

troponin I 354

trypsin 294 f.

tryptophan 362 tyrosine 291, 293, 362

UDP-Mur-Nac-pentapeptide synthetase enzyme (MurF) 163, 166, 169 ff. ultrafiltration 157 ff.

- membrane 179

- pulsed (PUF) 159, 177 ff., 367 ultraperformance liquid chromatography

(UPLC) 115 f., 415, 418 UV detection 98, 122, 126, 190, 223

v vancomycin 254 Vero-E6 cells 243 virus 335

w warfarin 133 ff. x

X-ray crystallography 135, 171, 311, 357, 361, 365, 367, 377, 387 f., 394

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