Selfassociation of Insulin A Protein Protein Interaction

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Protein-protein interactions mediate the majority of life processes. An understanding of these interactions is critical to understanding cell regulation [66] and to preventing human disease that can arise from errors in protein-protein interactions [67]. A clear understanding of these interactions points the way to developing new targets and discovering new drugs [68]. Insulin, a protein with 51 residues in two chains [69], is a good model system for testing whether a PLIMSTEX-like approach can determine protein self association. Oligomerization of insulin also has implications in the treatment of type I diabetes. The large size of the hexamer, which contains two Zn2+, of insulin prevents its efficient absorption into the blood stream [70], whereas aggregation is prevented by using analogs of insulins that are stable in monomeric form [71]. PLIMSTEX can be used to study the self-association properties of various insulins [33] and may be a promising method for investigating protein-protein interactions.

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Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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