1 R. Powers, M. M. Siegel: Applications of NMR and MS to anticancer drug discovery, in Novel Anti-Cancer Agents: Strategies for Discovery and Clinical Testing, ed. A. A. Adjei, J. K. Buolamwini, Elsevier Science, New York, 2006, pp 107-190.
2 M. M. Siegel: Mass spectrometry-based drug screening assays for early phases in drug discovery, in Integrated Strategies for Drug Discovery Using Mass Spectrometry, ed. Mike S. Lee, John Wiley & Sons, 2005, pp 27-70.
3 M. M. Siegel: Early discovery drug screening using mass spectrometry, Curr. Top. Med. Chem. 2002, 2, 1333.
4 J. A. Loo: Electrospray ionization mass spectrometry: a technology for studying noncovalent macromolecular complexes, Int. J. Mass Spectrom. 2000, 200, 175-186.
5 J. A. Loo, V. Thanabal, H.-Y. Mei: Studying noncovalent small molecule interactions with protein and RNA targets by mass spectrometry, Mass Spectrom. Biol. Med. 2000, 2000, 73-90.
6 J. A. Loo, K. A. Sannes-Lowery: Studying noncovalent interactions by electrospray ionization mass spectrometry, Mass Spectrom. Biol. Mater. 1990, 1998, 345-367.
7 J. A. Loo: Studying noncovalent protein complexes by electrospray ionization mass spectrometry, Mass Spectrom. Rev. 1997, 16, 1-23.
8 S. A. Hofstadler, R. H. Griffey: Analysis of noncovalent complexes of DNA and RNA by mass spectrometry, Chem. Rev. 2001, 101, 377-390.
9 R. D. Smith, J. E. Bruce, Q. Wu, Q. P. Lei: New Mass spectrometric methods for the study of noncovalent associations of biopolymers, Chem. Soc. Rev. 1997, 26, 191-202.
10 A. J. R. Heck: Ligand fishing by mass spectrometry, Spectrosc. Eur. 1999, 11, 12, 14, 16, 17.
11 M. M. Siegel, K. Tabei, G. A. Bebernitz, E. Z. Baum: A rapid method for screening low molecular weight compounds non-covalently bound to proteins using size exclusion and mass spectrometry applied to inhibitors of human cytomegalovirus protease, in Proceedings of the American Society for Mass Spectrometry and Allied Topics (45th ASMS Conference), Palm Springs, CA, 1997, WPD 124.
12 Y. M. Dunayevskiy, J.-J. Lai, C. Quinn, F. Talley, P. Vouros: Mass spec-trometric identification of ligands selected from combinatorial libraries using gel filtration, Rapid Commun. Mass Spectrom. 1997, 11, 1178-1184.
13 M. M. Siegel, K. Tabei, G. A. Bebernitz, E. Z. Baum: Rapid methods for screening low molecular mass compounds non-covalently bound to proteins using size exclusion and mass spectrometry applied to inhibitors of human cytomegalovirus protease, J. Mass Spectrom. 1998, 33, 264-273.
14 E. C. Hulme (ed.): Receptor-Ligand Interactions: A Practical Approach, Oxford University Press, Oxford, 1992.
15 F. J. Moy, K. Haraki, D. Mobilio, G. Walker, R. Powers, K. Tabei, H. Tong, M. M. Siegel: MS/NMR: a structure-based approach for discovering protein ligands and for drug design by coupling size exclusion chromatography, mass spectrometry, and nuclear magnetic resonance spectroscopy, Anal. Chem. 2001, 73, 571-581.
16 I. Muckenschnabel, R. Falchetto, L. M. Mayr, I. Filipuzzi: SpeedScreen: labelfree liquid chromatography-mass spectrometry-based high-throughput screening for the discovery of orphan protein ligands, Anal. Biochem. 2004, 324, 241-249.
17 E. J. Martin, R. E. Critchlow, D. C. Spellmeyer, S. Rosenberg, K. L. Spear, J. M. Blaney: Diverse approaches to combinatorial library design, Pharmacochem. Libr. 1998, 29, 133-146.
18 P. D. Schnier, R. Deblanc, G. Woo, W. Gigante, J. Cheetham: Ultra-high throughput affinity mass spectrome-try for screening protein receptors, in Proceedings of the 51st ASMS Conference on Mass Spectrometry and Allied Topics, Montreal, 2003, WPC 049.
19 I. Filipuzzi: SpeedScreen, a label-free, affinity-based high-throughput screening technology for the discovery of orphan protein ligands, Chimia 2004, 58, 585-587.
20 H. Zehender, F. le Goff, N. Lehmann, I. Filipuzzi, L. M. Mayr: SpeedScreen: the ''missing link'' between genomics and lead discovery, J. Biomol. Screen. 2004, 9, 498-505.
21 H. Tong, D. Bell, K. Tabei, M. M. Siegel: Automated data massaging, interpretation, and e-mailing modules for high throughput open access mass spectrometry, J. Am. Soc. Mass Spectrom. 1999, 10, 1174-1187.
22 H. Tong, K. Tabei, F. Moy, R. Powers, M. M. Siegel: Software package for the analysis of high-throughput drug screening data obtained by ESI/MS, in Proceedings of the American Society for Mass Spectrometry and Allied Topics (48th ASMS Conference), Long Beach, 2000, pp 935-936 (WPH320).
23 H. Tong, K. Tabei, A. Amin, M. Olson, G. Bebernitz, M. M. Siegel: Identification of compounds non-covalently bound to RNA using GPC spin columns with ESI MS detection, in Proceedings of the 49th American Society of Mass Spectrometry Conference on Mass Spectrometry & Allied Topics, Chicago, 2001, Poster Th 274.
A. Gilbert, K. Young: Applications of GPC spin column/ESI-MS for identifying non-covalent inhibitors of RGS4 protein, a potential CNS target, in Proceedings of the 52nd ASMS Conference on Mass Spectrometry and Allied Topics, Nashville, 2003.
25 S. Thaisrivongs, D. T. Pals, W. M. Kati, S. R. Turner, L. M. Thomasco, W. Watt: Design and synthesis of potent and specific renin inhibitors containing difluorostatine, difluorostatone, and related analogs, J. Med. Chem. 1986, 29, 2080-2087.
26 H. S. Shieh, R. G. Kurumbail, A. M. Stevens, R. A. Stegeman, E. J. Sturman, J. A. Pak, A. J. Wittwer, M. O. Palmier, R. C. Wiegand, B. C. Holwerda, W. C. Stallings: Three-dimensional structure of human cytomegalovirus protease, Nature 1996, 383, 279-282.
B. Hellmig, S. S. Hoog, C. A. Janson, W. W. Smith, S. S. Abdel-Meguid: Unique fold and active site in cytomegalovirus protease, Nature 1996, 383, 275-279.
28 L. Tong, C. Qian, M. J. Massariol, P. R. Bonneau, M. G. Cordingley,
L. Lagace: A new serine-protease fold revealed by the crystal structure of human cytomegalovirus protease, Nature 1996, 383, 272-275.
C. L. Gribskov, S. Katoh, D. L. Vanderpool, S. A., Margosiak,
Structure of the human cytomegalovirus protease catalytic domain reveals a novel serine protease fold and catalytic triad, Cell 1996, 86, 835-843.
30 P. J. Hajduk, G. Sheppard, D. G. Nettesheim, E. T. Olejniczak, S. B. Shuker, R. P. Meadows, D. H. Steinman, G. M. Carrera, Jr., P. A. Marcotte, J. Severin, K. Walter,
H. Smith, E. Gubbins, R. Simmer, T. F. Holzman, D. W. Morgan, S. K. Davidsen, J. B. Summers, S. W. Fesik: Discovery of potent nonpeptide inhibitors of stromelysin using SAR by NMR. J. Am. Chem. Soc. 1997, 119, 5818-5827.
31 D. A. Annis, N. Nazef, C.-C. Chuang, M. P. Scott, H. M. Nash: A general technique to rank protein-ligand binding affinities and determine allosteric versus direct binding site competition in compound mixtures. J. Am. Chem. Soc. 2004, 126, 15495-15503.
33 M. M. Zhu, D. L. Rempel, M. L. Gross: Modeling data from titration, amide H/D exchange, and mass spectrometry to obtain protein-ligand binding constants. J. Am. Soc. Mass Spectrom. 2004, 15, 388-397.
34 M. M. Zhu, D. L. Rempel, Z. Du, M. L. Gross: Quantification of protein-ligand interactions by mass spectrometry, titration, and H/D exchange: PLIMSTEX. J. Am. Chem. Soc. 2003, 125, 5252-5253.
35 R. G. Davis, R. J. Anderegg, S. G. Blanchard: Iterative size-exclusion chromatography coupled with liquid chromatographic mass spectrometry to enrich and identify tight-binding ligands from complex mixtures, Tetrahedron 1999, 55, 11653-11667.
36 P. A. Wabnitz, J. A. Loo: Drug screening of pharmaceutical discovery compounds by micro-size exclusion chromatography/mass spectrometry,
Rapid Commun. Mass Spectrom. 2002, 16, 85-91.
37 J. R. Mazzeo, U. D. Neue, M. Kele, R. S. Plumb: Advancing LC performance with smaller particles and higher pressure, Anal. Chem. 2005, 77, 460A-467A.
38 T. N. Corso, G. A. Schultz, J. Li, C. G. Alpha, B. I. Smith, N. A. Shinde,
J. C. Ackerman, G. S. Sheldon: A microchip-based multi-nozzle nano-electrospray device, in Proceedings of the 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, 2002, MPM 390, 1350.pdf, avaialble at: www.advion.com.
39 S. Zhang, C. K. Van Pelt, G. A. Schultz: Rapid, fully automated nano-ESI/MS/MS analysis of excised 2D gel spots by the nanomate robot and ESI chip, in Proceedings of the 50th ASMS Conference on Mass Spectrome-try and Allied Topics, Orlando, 2002, ThPB 025, 1549.pdf, available at: www.advion.com.
40 C. K. Van Pelt, S. Zhang, J. D. Henion: Characterizatioin of a fully automated nanospray system with mass spectrometric detection for proteomic analyses, J. Biomol. Tech. 2002, 13, 72-84.
T. Akerud, A. Sterling, P.-O. Edlund, J. Roeraade: Automated nano-electrospray mass spectrometry for protein-ligand screening by noncovalent interaction applied to human H-FABP and A-FABP, J. Biomol. Screen. 2003, 8, 247-256.
42 S. Zhang, C. K. Van Pelt, D. B. Wilson: Quantitative determination of noncovalent binding interactions using automated nanoelectrospray mass spectrometry, Anal. Chem. 2003, 75, 3010-3018.
43 R. E. Moore, L. Licklider, D. Schumann, T. D. Lee: A microscale electrospray interface incorporating a monolithic, poly(styrene-divinylbenzene) support for online liquid chromatography/tandem mass spectrometry analysis of peptides and proteins, Anal. Chem. 1998, 70, 48794884.
44 H. Liu, C. Felten, Q. Xue, B. Zhang, P. Jedrzejewski, B. L. Karger, F. Foret: Development of multichannel devices with an array of electrospray tips for high-throughput mass spectrometry, Anal. Chem. 2000, 72, 3303-3310.
45 K. Tang, Y. Lin, D. W. Matson, T. Kim, R. D. Smith: Generation of multiple electrosprays using microfabricated emitter arrays for improved mass spectrometric sensitivity, Anal. Chem. 2001, 73, 1658-1663.
46 S. Zhang, X. Huang: A microchip electrospray device and column with affinity adsorbents and use of the same, PCT Int. Appl. 2002, 59 pp, WO 0266135 A1 20020829.
47 C. A. S. Barnes, D. E. Clemmer: Assessment of purity and screening of peptide libraries by nested ion mobility-TOFMS: identification of RNase S-protein binders. Anal. Chem. 2001, 73, 424-433.
48 Z. Shen, J. J. Thomas, C. Averbuj, K. M. Broo, M. Engelhard, J. E. Crowell, M. G. Finn, G. Siuzdak: Porous silicon as a versatile platform for laser desorp-tion/ionization mass spectrometry, Anal. Chem. 2001, 73, 612-619.
49 G. E. Siuzdak, J. Buriak, J. Wei: Improved desorption/ionization of analytes from porous light-absorbing semiconductor, PCT Int. Appl. 2000, 76 pp, WO0054309 A1 20000914.
50 J. Wei, J. M. Buriak, G. Siuzdak: Desorption-ionization mass spectrometry on porous silicon, Nature 1999, 399, 243-246.
52 M. Holmquist, A. Palm, J. Engstrom, U. Selditz, P. Andersson: High-speed protein digestion, sample preparation and MALDI-TOF MS peptide mapping on a microfluidic compact disc (CD), in Proceedings of the 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, 2002, WPP 238, 2066.pdf, available at: www.gyros.com.
53 M. Gustafsson, E. Togan-Tekin,
G. Ekstrand, R. Kange, P. Andersson, S. Wallenborg: A CD microlaboratory for improved protein identification by MALDI MS, in Proceedings of the 50th ASMS Conference on Mass Spectrome-try and Allied Topics, Orlando, 2002, ThPA 004, 1558.pdf,available at: www.gyros.com.
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