References

2 Korfmacher, W.: Using Mass Spectrometry for Drug Metabolism-Studies, CRC Press, Boca Raton, 2005, 370 pp.

1 Frank, R.; Hargreaves, R.: Clinical biomarkers in drug discovery and development. Nat Rev Drug Discov 2003, 2, 566-580.

6 Korfmacher, W.: Bioanalytical assays in a drug discovery environment, in Using Mass Spectrometry for Drug Metabolism Studies, CRC Press, Boca Raton, 2005, pp 1-34.

3 Lee, M. S.: Integrated Strategies for Drug Discovery using Mass Spectrometry, John Wiley & Sons, Hoboken, 2005, 550 pp.

7 Olah, T. V.: The development and implementation of bioanalytical methods using LC-MS to support ADME studies in early drug discovery and candidate selection. Ernst Schering Res Found Workshop 2002, 155-183.

4 Korfmacher, W. A.; Cox, K. A.; Bryant, M. S.; Veals, J.; Ng, K.; et al.: HPLC-API/MS/MS: a powerful tool for integrating drug metabolism into the drug discovery process. Drug Discov Today 1997, 2, 532-537.

8 Korfmacher, W.: New strategies for the implementation and support of bioanalysis in a drug metabolism environment, in Integrated Strategies for Drug Discovery using Mass Spectrometry, John Wiley & Sons, Hoboken, 2005, pp 359378.

5 Korfmacher, W. A.: Lead optimization strategies as part of a drug metabolism environment. Curr Opin Drug Discov Dev 2003, 6, 481-485.

9 Korfmacher, W. A.: Principles and applications of LC-MS in new drug discovery. Drug Discov Today 2005, 10, 1357-1367.

10 Xu, X.; Lan, J.; Korfmacher, W.: Rapid LC/MS/MS method development for drug discovery. Anal Chem 2005, 77, 389A-394A.

11 Lim, C. K.; Lord, G.: Current developments in LC-MS for pharmaceutical analysis. Biol Pharm Bull 2002, 25, 547-557.

12 Roberts, S. A.: High-throughput screening approaches for investigating drug metabolism and pharmacokinetics. Xenobiotica 2001, 31, 557-589.

13 Beresford, A. P.; Selick, H. E.; Tarbit, M. H.: The emerging importance of predictive ADME simulation in drug discovery. Drug Discov Today 2002, 7, 109-116.

14 Eddershaw, P. J.; Beresford, A. P.; Bayliss, M. K.: ADME/PK as part of a rational approach to drug discovery. Drug Discov Today 2000, 5, 409-414.

15 Jenkins, K. M.; Angeles, R.; Quintos, M. T.; Xu, R.; Kassel, D. B.; et al.: Automated high throughput ADME assays for metabolic stability and cytochrome P450 inhibition profiling of combinatorial libraries. J Pharm Biomed Anal 2004, 34, 989-1004.

16 Kassel, D. B.: High throughput strategies for in vitro ADME assays: how fast can we go? in Using Mass Spectrometry for Drug Metabolism Studies, CRC Press, Boca Raton, 2005.

17 O'Connor, D.: Automated sample preparation and LC-MS for high-throughput ADME quantification. Curr Opin Drug Discov Dev 2002, 5, 52-58.

18 Thompson, T. N.: Early ADME in support of drug discovery: the role of metabolic stability studies. Curr Drug Metab 2000, 1, 215-241.

19 Kumar, G. N.; Surapaneni, S.: Role of drug metabolism in drug discovery and development. Med Res Rev 2001, 21, 397-411.

20 Riley, R. J.; Martin, I. J.; Cooper, A. E.: The influence of DMPK as an integrated partner in modern drug discovery. Curr Drug Metab 2002, 3, 527-550.

21 Crowley, P. J.; Martini, L. G.: Enhancing oral absorption in animals. Curr Opin Drug Discov Dev 2004, 4, 73-80.

22 Thompson, T. N.: Drug metabolism in vitro and in vivo results: how do these data support drug discovery, in Using Mass Spectrometry for Drug Metabolism Studies, CRC Press, Boca Raton, 2005; pp 35-82.

23 Ackermann, B. L.; Berna, M. J.; Murphy, A. T.: Recent advances in use of LC/MS/MS for quantitative high-throughput bioanalytical support of drug discovery. Curr Top Med Chem 2002, 2, 53-66.

24 Miller-Stein, C.; Bonfiglio, R.; Olah, T. V.; King, R. C.: Rapid method development of quantitative LC-MS/ MS assays for drug discovery. Am Pharm Rev 2000, 3, 54-61.

25 Oliveira, E. J.; Watson, D. G.: Liquid chromatography-mass spectrometry in the study of the metabolism of drugs and other xenobiotics. Biomed Chromatogr 2000, 14, 351-372.

26 Rossi, D. T.; Sinz, M.: Mass Spectrometry in Drug Discovery, Marcel Dekker, New York, 2002.

27 Kyranos, J. N.; Cai, H.; Wei, D.; Goetzinger, W. K.: High-throughput high-performance liquid chromatography/mass spectrometry for modern drug discovery. Curr Opin Biotechnol 2001, 12, 105-111.

28 Hopfgartner, G.; Husser, C.; Zell, M.: High-throughput quantification of drugs and their metabolites in biosamples by LC-MS/MS and CE-MS/MS: possibilities and limitations. Ther Drug Monit 2002, 24, 134-143.

29 Jemal, M.: High-throughput quantitative bioanalysis by LC/MS/ MS. Biomed Chromatogr 2000, 14, 422-429.

30 Lee, M. S.; Kerns, E. H.: LC/MS applications in drug development. Mass Spectrom Rev 1999, 18, 187-279.

31 Siegel, M. M.: Early discovery drug screening using mass spectrometry. Curr Top Med Chem 2002, 2, 13-33.

32 Fernandez-Metzler, C.; Subramanian, R.; King, R. C.: Application of technological advances in biotransformation studies, in Integrated Strategies for Drug Discovery using Mass Spectrometry, John Wiley & Sons, Hoboken, 2005, pp 261-288.

33 Cox, K.: Special requirements for metabolite characterization, in Using Mass Spectrometry for Drug Metabolism Studies, CRC Press, Boca Raton, 2005, pp 229-252.

34 Hopfgartner, G.; Husser, C.; Zell, M.: Rapid screening and characterization of drug metabolites using a new quadrupole-linear ion trap mass spectrometer. J Mass Spectrom 2003, 38, 138-150.

35 Hopfgartner, G.; Varesio, E.; Tschappat, V.; Grivet, C.; Bourgogne, E.; et al.: Triple quadrupole linear ion trap mass spectrometer for the analysis of small molecules and macromolecules. J Mass Spectrom 2004, 39, 845-855.

36 Leclercq, L.; Delatour, C.; Hoes, I.; Brunelle, F.; Labrique, X.; et al.: Use of a five-channel multiplexed electrospray quadrupole time-of-flight hybrid mass spectrometer for metabolite identification. Rapid Commun Mass Spectrom 2005, 19, 1611-1618.

37 Clarke, N. J.; Rindgen, D.; Korfmacher, W. A.; Cox, K. A.: Systematic LC/MS metabolite identification in drug discovery. Anal Chem 2001, 73, 430A-439A.

38 Hopfgartner, G.; Zell, M.: Q trap MS: a new tool for metabolite identification, in Using Mass Spectrometry for Drug Metabolism Studies, CRC Press, Boca Raton, 2005.

39 Brotherton, H. O.; Yost, R. A.: Determination of drugs in blood serum by mass spectrometry/mass spectrome-try. Anal Chem 1983, 55, 549-553.

40 van De Waterbeemd, H.; Smith, D. A.; Beaumont, K.; Walker, D. K.: Property-based design: optimization of drug absorption and pharmaco-kinetics. J Med Chem 2001, 44, 13131333.

41 van de Waterbeemd, H.; Jones, B. C.: Predicting oral absorption and bioavailability. Prog Med Chem 2003, 41, 1-59.

42 Caldwell, G. W.; Ritchie, D. M.; Masucci, J. A.; Hageman, W.; Yan, Z.: The new pre-preclinical paradigm: compound optimization in early and late phase drug discovery. Curr Top Med Chem 2001, 1, 353-366.

43 van de Waterbeemd, H.: Which in vitro screens guide the prediction of oral absorption and volume of distribution? Basic Clin Pharmacol Toxicol 2005, 96, 162-166.

44 Thompson, T. N.: Optimization of metabolic stability as a goal of modern drug design. Med Res Rev 2001, 21, 412-449.

45 Bertrand, M.; Jackson, P.; Walther, B.: Rapid assessment of drug metabolism in the drug discovery process. Eur J Pharm Sci 2000, 11 [Suppl 2], S61-S72.

46 Chaturvedi, P. R.; Decker, C. J.; Odinecs, A.: Prediction of pharmacokinetic properties using experimental approaches during early drug discovery. Curr Opin Chem Biol 2001, 5, 452-463.

47 Kassel, D. B.: Applications of high-throughput ADME in drug discovery. Curr Opin Chem Biol 2004, 8, 339345.

48 Naritomi, Y.; Terashita, S.; Kimura, S.; Suzuki, A.; Kagayama, A.; et al.: Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans. Drug Metab Dispos 2001, 29, 1316-1324.

49 Ansede, J. H.; Thakker, D. R.: High-throughput screening for stability and inhibitory activity of compounds toward cytochrome P450-mediated metabolism. J Pharm Sci 2004, 93, 239-255.

50 Korfmacher, W. A.; Palmer, C. A.; Nardo, C.; Dunn-Meynell, K.; Grotz, D.; et al.: Development of an automated mass spectrometry system for the quantitative analysis of liver microsomal incubation samples: a tool for rapid screening of new compounds for metabolic stability. Rapid Commun Mass Spectrom 1999, 13, 901-907.

51 Di, L.; Kerns, E. H.; Hong, Y.; Kleintop, T. A.; McConnell, O. J.; et al.: Optimization of a higher throughput microsomal stability screening assay for profiling drug discovery candidates. J Biomol Screen 2003, 8, 453-462.

52 Xu, R.; Nemes, C.; Jenkins, K. M.; Rourick, R. A.; Kassel, D. B.; et al.: Application of parallel liquid chromatography/mass spectrometry for high throughput microsomal stability screening of compound libraries. J Am Soc Mass Spectrom 2002, 13, 155-165.

53 Li, Y.; Shin, Y. G.; Yu, C.; Kosmeder, J. W.; Hirschelman, W. H.; et al.: Increasing the throughput and productivity of Caco-2 cell permeability assays using liquid chromatography-mass spectrometry: application to resveratrol absorption and metabolism. Comb Chem High Throughput Screen 2003, 6, 757-767.

54 Mandagere, A. K.; Thompson, T. N.; Hwang, K. K.: Graphical model for estimating oral bioavailability of drugs in humans and other species from their Caco-2 permeability and in vitro liver enzyme metabolic stability rates. J Med Chem 2002, 45, 304-311.

55 Balimane, P. V.; Chong, S.: Cell culture-based models for intestinal permeability: a critique. Drug Discov Today 2005, 10, 335-343.

56 Bu, H. Z.; Poglod, M.; Micetich, R. G.; Khan, J. K.: High-throughput caco-2 cell permeability screening by cassette dosing and sample pooling approaches using direct injection/online guard cartridge extraction/ tandem mass spectrometry. Rapid Commun Mass Spectrom 2000, 14, 523-528.

57 Fung, E. N.; Chu, I.; Li, C.; Liu, T.; Soares, A.; et al.: Higher-throughput screening for Caco-2 permeability utilizing a multiple sprayer liquid chromatography/tandem mass spectrometry system. Rapid Commun Mass Spectrom 2003, 17, 2147-2152.

58 Hakala, K. S.; Laitinen, L.; Kaukonen, A. M.; Hirvonen, J.; Kostiainen, R.;

et al.: Development of LC/MS/MS

methods for cocktail dosed Caco-2 samples using atmospheric pressure photoionization and electrospray ionization. Anal Chem 2003, 75, 5969-5977.

59 Larger, P.; Altamura, M.; Catalioto, R. M.; Giuliani, S.; Maggi, C. A.; et al.: Simultaneous LC-MS/MS determination of reference pharmaceuticals as a method for the characterization of the Caco-2 cell monolayer absorption properties. Anal Chem 2002, 74, 5273-5281.

60 Wang, Z.; Hop, C. E.; Leung, K. H.; Pang, J.: Determination of in vitro permeability of drug candidates through a caco-2 cell monolayer by liquid chromatography/tandem mass spectrometry. J Mass Spectrom 2000, 35, 71-76.

61 Kariv, I.; Rourick, R. A.; Kassel, D. B.; Chung, T. D.: Improvement of "hit-to-lead" optimization by integration of in vitro HTS experimental models for early determination of pharmacokinetic properties. Comb Chem High Throughput Screen 2002, 5, 459-472.

62 White, R. E.: High-throughput screening in drug metabolism and pharmacokinetic support of drug discovery. Annu Rev Pharmacol Toxicol 2000, 40, 133-157.

63 Yan, Z.; Caldwell, G. W.: Metabolism profiling, and cytochrome P450 inhibition & induction in drug discovery. Curr Top Med Chem 2001, 1, 403-425.

64 Bjornsson, T. D.; Callaghan, J. T.; Einolf,H. J.; Fischer, V.; Gan, L.;

et al.: The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective. Drug Metab Dispos 2003, 31, 815-832.

65 Obach, R. S.: Drug-drug interactions: an important negative attribute in drugs. Drugs Today 2003, 39, 301338.

66 Obach, R. S.; Walsky, R. L.; Venkatakrishnan, K.; Gaman, E. A.; Houston, J. B.; et al.: The utility of in vitro cytochrome p450 inhibition data in the prediction of drug-drug interactions. J Pharmacol Exp Ther 2005.

C.; Nomeir, A. A.: Validation of higher-throughput high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry assays to conduct cytochrome P450s CYP2D6 and CYP3A4 enzyme inhibition studies in human liver microsomes. Rapid Commun Mass Spectrom 2000, 14, 207-214.

68 Bu, H. Z.; Magis, L.; Knuth, K.; Teitelbaum, P.: High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. VI. Simultaneous evaluation of inhibition potential of drugs on human hepatic isozymes CYP2A6, 3A4, 2C9, 2D6 and 2E1. Rapid Commun Mass Spectrom 2001, 15, 741-748.

69 Testino, S. A. Jr.; Patonay, G.: High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal 2003, 30, 1459-1467.

D. M.: High-throughput cytochrome p450 inhibition assays by ultrafast gradient liquid chromatography with tandem mass spectrometry using monolithic columns. Rapid Commun Mass Spectrom 2003, 17, 509-518.

71 Kim, M. J.; Kim, H.; Cha, I. J.; Park, J. S.; Shon, J. H.; et al.: High-throughput screening of inhibitory potential of nine cytochrome P450 enzymes in vitro using liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 2005, 19, 2651-2658.

72 Cox, K. A.; White, R. E.; Korfmacher, W. A.: Rapid determination of pharmacokinetic properties of new chemical entities: in vivo approaches. Comb Chem High Throughput Screen 2002, 5, 29-37.

73 Hopfgartner, G.; Bourgogne, E.: Quantitative high-throughput analysis of drugs in biological matrices by mass spectrometry. Mass Spectrom Rev

74 Ong, V. S.; Cook, K. L.; Kosara, C. M.; Brubaker, W. F.: Quantitative bioanalysis: an integrated approach for drug discovery and development. Int J Mass Spectrom 2004, 238, 139152.

75 Chaikin, P.; Rhodes, G. R.; Bruno, R.; Rohatagi, S.; Natarajan, C.: Pharmacokinetics/pharmacodynamics in drug development: an industrial perspective. J Clin Pharmacol 2000, 40, 1428-1438.

76 Derendorf,H.; Lesko, L. J.; Chaikin, P.; Colburn, W. A.; Lee, P.; et al.: Pharmacokinetic/pharmacodynamic modeling in drug research and development. J Clin Pharmacol 2000, 40, 1399-1418.

77 Rohatagi, S.: A future in pharmaco-kinetic and pharmacodynamic modeling. Curr Drug Discov 2004,

78 Manitpisitkul, P.; White, R. E.: Whatever happened to cassette-dosing pharmacokinetics? Drug Discov Today 2004, 9, 652-658.

79 White, R. E.; Manitpisitkul, P.: Pharmacokinetic theory of cassette dosing in drug discovery screening. Drug Metab Dispos 2001, 29, 957966.

80 Smith, N. F.; Hayes, A.; Nutley, B. P.; Raynaud, F. I.; Workman, P.: Evaluation of the cassette dosing approach for assessing the pharmacokinetics of geldanamycin analogues in mice. Cancer Chemother Pharmacol 2004.

81 Tamvakopoulos, C. S.; Colwell, L. F.; Barakat, K.; Fenyk-Melody, J.; Griffin, P. R.; et al.: Determination of brain and plasma drug concentrations by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 2000, 14, 1729-1735.

82 Ohkawa, T.; Ishida, Y.; Kanaoka, E.; Takahashi, K.; Okabe, H.; et al.: A new generic column switching system for quantitation in cassette dosing using LC/MS/MS. J Pharm Biomed Anal 2003, 31, 1089-1099.

83 Zhang, M. Y.; Kerns, E.; McConnell, O.; Sonnenberg-Reines, J.; Zaleska, M. M.; et al.: Brain and plasma exposure profiling in early drug discovery using cassette administration and fast liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal 2004, 34, 359-368.

84 Sadagopan, N.; Pabst, B.; Cohen, L.: Evaluation of online extraction/mass spectrometry for in vivo cassette analysis. J Chromatogr B Anal Technol Biomed Life Sci 2005, 820, 59-67.

85 Korfmacher, W. A.; Cox, K. A.; Ng, K. J.; Veals, J.; Hsieh, Y.; et al.: Cassette-accelerated rapid rat screen: a systematic procedure for the dosing and liquid chromatography/ atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discovery. Rapid Commun Mass Spectrom 2001, 15, 335-340.

86 Hsieh, Y.; Wang, G.; Wang, Y.; Chackalamannil, S.; Brisson, J. M.;

et al.: Simultaneous determination of a drug candidate and its metabolite in rat plasma samples using ultrafast monolithic column high-performance liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 2002, 16, 944-950.

87 Hsieh, Y.; Brisson, J. M.; Wang, G.; Ng, K.; Korfmacher, W. A.: Simultaneous fast HPLC-MS/MS analysis of drug candidates and hydroxyl metabolites in plasma.

J Pharm Biomed Anal 2003, 33, 251-261.

88 Jemal, M.; Ouyang, Z.: Enhanced resolution triple-quadrupole mass spectrometry for fast quantitative bioanalysis using liquid chromatography/tandem mass spectrometry: investigations of parameters that affect ruggedness. Rapid Commun Mass Spectrom 2003, 17, 24-38.

89 Hsieh, Y.; Brisson, J.-M.; Wang, G.: Fast HPLC-MS/MS for small molecules. Am Pharm Rev 2003, 6, 14-20.

90 Romanyshyn, L.; Tiller, P. R.; Alvaro, R.; Pereira, A.; Hop, C. E.: Ultra-fast gradient vs fast isocratic chroma-tography in bioanalytical quantification by liquid chromatography/ tandem mass spectrometry. Rapid Commun Mass Spectrom 2001, 15, 313-319.

91 Romanyshyn, L. A.; Tiller, P. R.: Ultra-short columns and ballistic gradients: considerations for ultra-fast chromatographic liquid chromatographic-tandem mass spectrometric analysis. J Chromatogr A 2001, 928, 41-51.

92 Shou, W. Z.; Chen, Y. L.; Eerkes, A.; Tang, Y. Q.; Magis, L.; et al.: Ultrafast liquid chromatography/tandem mass spectrometry bioanalysis of polar analytes using packed silica columns. Rapid Commun Mass Spectrom 2002, 16, 1613-1621.

93 Smith, J. H.; McNair, H. M.: Fast HPLC with a Silica-Based Monolithic ODS Column. J Chromatogr Sci 2003, 41, 209-214.

94 Tiller, P. R.; Romanyshyn, L. A.; Neue, U. D.: Fast LC/MS in the analysis of small molecules. Anal Bioanal Chem 2003, 377, 788-802.

95 Zeng, H.; Deng, Y.; Wu, J. T.: Fast analysis using monolithic columns coupled with high-flow on-line extraction and electrospray mass spectrometric detection for the direct and simultaneous quantitation of multiple components in plasma.

J Chromatogr B Anal Technol Biomed Life Sci 2003, 788, 331-337.

96 Romanyshyn, L.; Tiller, P. R.; Hop, C. E.: Bioanalytical applications of 'fast chromatography' to high-throughput liquid chromatography/ tandem mass spectrometric quantitation. Rapid Commun

Mass Spectrom 2000, 14, 16621668.

97 Hsieh, Y.; Chintala, M.; Mei, H.; Agans, J.; Brisson, J. M.; et al.: Quantitative screening and matrix effect studies of drug discovery compounds in monkey plasma using fast-gradient liquid chromatography/ tandem mass spectrometry. Rapid

Commun Mass Spectrom 2001, 15, 2481-2487.

98 Tiller, P. R.; Romanyshyn, L. A.: Implications of matrix effects in ultra-fast gradient or fast isocratic liquid chromatography with mass spectrometry in drug discovery. Rapid Commun Mass Spectrom 2002, 16, 92-98.

99 Dunn-Meynell, K. W.; Wainhaus, S.; Korfmacher, W. A.: Optimizing an ultrafast generic high-performance liquid chromatography/tandem mass spectrometry method for faster discovery pharmacokinetic sample throughput. Rapid Commun Mass Spectrom 2005, 19, 2905-2910.

100 Tanak, N.; Kobayashi, H.; Ishizuka, N.; Minakuchi, H.; Nakanishi, K.; et al.: Monolithic silica columns for high-efficiency chromatographic separations. J Chromatogr A 2002, 965, 35-49.

101 Tanaka, N.; Kobayashi, H.; Nakanishi, K.; Minakuchi, H.; Ishizuka, N.: Monolithic LC columns. Anal Chem 2001, 73, 420A-429A.

102 Tanaka, N.; Kobayashi, H.: Monolithic columns for liquid chromatography. Anal Bioanal Chem 2003, 376, 298-301.

103 Wu, J. T.; Zeng, H.; Deng, Y.; Unger, S. E.: High-speed liquid chromatography/tandem mass spectrometry using a monolithic column for high-throughput bioanalysis. Rapid Commun Mass Spectrom 2001, 15, 1113-1119.

104 van de Merbel, N. C.; Poelman, H.: Experiences with monolithic LC phases in quantitative bioanalysis.

J Pharm Biomed Anal 2004, in press.

105 Hsieh, Y.; Wang, G.; Wang, Y.; Chackalamannil, S.; Korfmacher,

W. A.: Direct plasma analysis of drug compounds using monolithic column liquid chromatography and tandem mass spectrometry. Anal Chem 2003, 75, 1812-1818.

106 Jarmalaviciene, R.; Kornysova, O.; Westerlund, D.; Maruska, A.: Non-particulate (continuous bed or monolithic) restricted-access reversed-phase media for sample clean-up and separation by capillary-format liquid chromatography. Anal Bioanal Chem 2003, 377, 902-908.

107 Barbarin, N.; Mawhinney, D. B.; Black, R.; Henion, J.: High-throughput selected reaction monitoring liquid chromatography-mass spectrometry determination of methylphenidate and its major metabolite, ritalinic acid, in rat plasma employing monolithic columns. J Chromatogr B Anal Technol Biomed Life Sci 2003, 783, 73-83.

108 Korfmacher, W. A.; Veals, J.; Dunn-Meynell, K.; Zhang, X.; Tucker, G.; et al.: Demonstration of the capabilities of a parallel high performance liquid chromatography tandem mass spectrometry system for use in the analysis of drug discovery plasma samples. Rapid Commun Mass Spectrom 1999, 13, 1991-1998.

109 Jemal, M.; Huang, M.; Mao, Y.; Whigan, D.; Powell, M. L.: Increased throughput in quantitative bioanalysis using parallel-column liquid chromatography with mass spectrometric detection. Rapid Commun Mass Spectrom 2001, 15, 994-999.

C. L.; Olah, T. V.; et al.: High-speed gradient parallel liquid chromatography/tandem mass spectrometry with fully automated sample preparation for bioanalysis: 30 seconds per sample from plasma. Rapid Commun Mass Spectrom 2002, 16, 1116-1123.

111 Wu, J. T.: The development of a staggered parallel separation liquid chromatography/tandem mass spectrometry system with on-line extraction for high-throughout screening of drug candidates in biological fluids. Rapid Commun Mass Spectrom 2001, 15, 73-81.

D. J.; Brann, J.: Description and validation of a staggered parallel high performance liquid chromatography system for good laboratory practice level quantitative analysis by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 2002, 16, 43-52.

113 Xu, X.; Zhou, Q.; Korfmacher, W. A.: Development of a low volume plasma sample precipitation procedure for liquid chromatography/tandem mass spectrometry assays used for drug discovery applications. Rapid Commun Mass Spectrom 2005, 19, 2131-2136.

114 Liang, H. R.; Foltz, R. L.; Meng, M.; Bennett, P.: Ionization enhancement in atmospheric pressure chemical ionization and suppression in electrospray ionization between target drugs and stable-isotope-labeled internal standards in quantitative liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 2003, 17, 2815-2821.

115 Mei, H.; Hsieh, Y.; Nardo, C.; Xu, X.; Wang, S.; et al.: Investigation of matrix effects in bioanalytical highperformance liquid chromatography/ tandem mass spectrometric assays: application to drug discovery. Rapid Commun Mass Spectrom 2003, 17, 97-103.

116 Schuhmacher, J.; Zimmer, D.; Tesche, F.; Pickard, V.: Matrix effects during analysis of plasma samples by electrospray and atmospheric pressure chemical ionization mass spectrometry: practical approaches to their elimination. Rapid Commun Mass Spectrom 2003, 17, 1950-1957.

J. L.: Matrix effect in LC-ESI-MS and LC-APCI-MS with off-line and on-line extraction procedures. J Chromatogr A 2004, 1058, 61-66.

118 Taylor, P. J.: Matrix effects: the Achilles heel of quantitative highperformance liquid chromatography-electrospray-tandem mass spectrometry. Clin Biochem 2005, 38, 328-334.

119 Xu, X.; Mei, H.; Wang, S.; Zhou, Q.; Wang, G.; et al.: A study of common discovery dosing formulation components and their potential for causing time-dependent matrix effects in high-performance liquid chromatography tandem mass spectrometry assays. Rapid Commun Mass Spectrom 2005, 19, 2643-2650.

S. E.: Comparison of SPE and fast LC to eliminate mass spectrometric matrix effects from microsomal incubation products. J Pharm Biomed Anal 2002, 28, 279-285.

121 King, R.; Bonfiglio, R.; Fernandez-Metzler, C.; Miller-Stein, C.; Olah, T.: Mechanistic investigation of ionization suppression in electrospray ionization. J Am Soc Mass Spectrom 2000, 11, 942-950.

122 Matuszewski, B. K.; Constanzer, M. L.; Chavez-Eng, C. M.: Matrix effect in quantitative LC/MS/MS analyses of biological fluids: a method for determination of finasteride in human plasma at picogram per milliliter concentrations. Anal Chem 1998, 70, 882-889.

123 Matuszewski, B. K.; Constanzer, M. L.; Chavez-Eng, C. M.: Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal Chem 2003, 75, 3019-3030.

124 Mei, H.: Matrix effects: causes and solutions, in Using Mass Spectrometry for Drug Metabolism Studies, CRC Press, Boca Raton, 2005, pp 103150.

125 Shou, W. Z.; Naidong, W.: Post-column infusion study of the 'dosing vehicle effect' in the liquid chromatography/tandem mass spectrometric analysis of discovery pharmacokinetic samples. Rapid Commun Mass Spectrom 2003, 17, 589-597.

126 Tong, X. S.; Wang, J.; Zheng, S.; Pivnichny, J. V.; Griffin, P. R.; et al.: Effect of signal interference from dosing excipients on pharmacokinetic screening of drug candidates by liquid chromatography/mass spectrometry. Anal Chem 2002, 74, 6305-6313.

127 Larger, P. J.; Breda, M.; Fraier, D.; Hughes, H.; James, C. A.: Ion-suppression effects in liquid chromatography-tandem mass spectrometry due to a formulation agent, a case study in drug discovery bioanalysis. J Pharm Biomed Anal 2005, 39, 206-216.

128 Bajpai, M.; Esmay, J. D.: In vitro studies in drug discovery and development: an analysis of study objectives and application of good laboratory practices (GLP). Drug Metab Rev 2002, 34, 679-689.

129 Shabir, G. A.: Validation of highperformance liquid chromatography methods for pharmaceutical analysis. Understanding the differences and similarities between validation requirements of the US Food and Drug Administration, the US Pharmacopeia and the International Conference on Harmonization.

J Chromatogr A 2003, 987, 57-66.

130 Sherma, J.: UPLC: Ultra-performance liquid chromatography. J AOAC Int 2005, 88, 63A-67A.

131 Wren, S. A.: Peak capacity in gradient ultra performance liquid chromatography (UPLC). J Pharm Biomed Anal 2005, 38, 337-343.

132 Churchwell, M. I.; Twaddle, N. C.; Meeker, L. R.; Doerge, D. R.: Improving LC-MS sensitivity through increases in chromatographic performance: comparisons of UPLC-ES/MS/MS to HPLC-ES/MS/MS.

J Chromatogr B Anal Technol Biomed Life Sci 2005.

133 Johnson, K. A.; Plumb, R.: Investigating the human metabolism of acetaminophen using UPLC and exact mass oa-TOF MS. J Pharm Biomed Anal 2005.

134 Plumb, R. S.; Granger, J. H.; Stumpf, C. L.; Johnson, K. A.; Smith, B. W.; et al.: A rapid screening approach to metabonomics using UPLC and oa-TOF mass spectrometry: application to age, gender and diurnal variation in normal/Zucker obese rats and black, white and nude mice. Analyst 2005, 130, 844-849.

135 Shen, J. X.; Wang, H.; Tadros, S.; Hayes, R. N.: Orthogonal extraction/ chromatography and UPLC, two powerful new techniques for bioana-lytical quantitation of desloratadine and 3-hydroxydesloratadine at

25 pg/mL. J Pharm Biomed Anal 2005.

136 Castro-Perez, J.; Plumb, R.; Granger, J. H.; Beattie, I.; Joncour, K.; et al.: Increasing throughput and information content for in vitro drug metabolism experiments using ultraperformance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer. Rapid Commun Mass Spectrom 2005, 19, 843-848.

137 Plumb, R.; Castro-Perez, J.; Granger, J.; Beattie, I.; Joncour, K.; et al.: Ultraperformance liquid chromatography coupled to quadrupole-orthogonal time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 2004, 18, 2331-2337.

138 Li, A. C.; Alton, D.; Bryant, M. S.; Shou, W. Z.: Simultaneously quantifying parent drugs and screening for metabolites in plasma pharmacokinetic samples using selected reaction monitoring information-dependent acquisition on a QTrap instrument. Rapid Commun Mass Spectrom 2005, 19, 1943-1950.

139 Xu, X.: Using higher mass resolution in quantitative assays, in Using Mass Spectrometry for Drug Metabolism Studies, CRC Press, Boca Raton, 2005, pp 203-228.

140 Xu, X.; Veals, J.; Korfmacher, W. A.: Comparison of conventional and enhanced mass resolution triple-quadrupole mass spectrometers for discovery bioanalytical applications. Rapid Commun Mass Spectrom 2003, 17, 832-837.

141 Hsieh, Y.; Wang, G.: Normal phase HPLC-APPI/MS/MS determination of stereoisomeric mixtures, in Eastern Analytical Symposium, Somerset, N.J., 2003.

142 Hsieh, Y.: APPI: a new ionization source for LC-MS/MS assays, in Using Mass Spectrometry for Drug Metabolism Studies, CRC Press, Boca Raton, 2005, pp 253-276.

143 Cai, Y.; Kingery, D.; McConnell, O.; Bach, A. C. 2nd: Advantages of atmospheric pressure photoionization mass spectrometry in support of drug discovery. Rapid Commun Mass Spectrom 2005, 19, 1717-1724.

144 Hsieh, Y.; Wang, G.: Integration of atmospheric pressure photoionization interfaces to HPLC-MS/MS for pharmaceutical analysis. Am Pharm Rev 2004, 7, 88-93.

145 Kauppila, T. J.; Kuuranne, T.; Meurer, E. C.; Eberlin, M. N.; Kotiaho, T.;

et al.: Atmospheric pressure photoionization mass spectrometry. Ionization mechanism and the effect of solvent on the ionization of naphthalenes. Anal Chem 2002, 74, 5470-5479.

146 Kauppila, T. J.; Kotiaho, T.; Kostiainen, R.; Bruins, A. P.: Negative ion-atmospheric pressure photoioniza-tion-mass spectrometry. J Am Soc Mass Spectrom 2004, 15, 203-211.

147 McKenzie, D. E.; McDermott, L. L.: LC-MS investigation of atmospheric pressure photoionization versus electrospray ionization and atmospheric pressure chemical ionization using eleven test compounds, in 51st ASMS Conference on Mass Spectrometry and Allied Topics, ASMS, Montreal, 2003.

148 Raffaelli, A.; Saba, A.: Atmospheric pressure photoionization mass spectrometry. Mass Spectrom Rev 2003, 22, 318-331.

149 Syage, J. A.; Evans, M. D.: Photoionization mass spectrometry. Spectroscopy 2001, 16, 14-22.

150 Wang, G.; Hsieh, Y.; Korfmacher, W. A.: Comparison of atmospheric pressure chemical ionization, electrospray ionization, and atmospheric pressure photoionization for the determination of cyclosporin a in rat plasma. Anal Chem 2005, 77, 541-548.

151 Yang, C.; Henion, J.: Atmospheric pressure photoionization liquid chromatographic-mass spectrometric determination of idoxifene and its metabolites in human plasma.

J ChromatogrA 2002, 970, 155-165.

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