Peroxisome Proliferatoractivated Receptor g

Peroxisome proliferator-activated receptor g (PPARg) is a ligand-dependent transcription factor that is involved in glucose homeostasis and adipocyte differentiation, and is the molecular target of anti-diabetic agents, such as rosiglitazone. Many studies on this class of receptors indicate that the binding to agonists or antagonists induces different conformational changes in the ligand binding domain (LBD) [59-63]. These conformational changes induced by various biological modulators have been proposed to have key roles in the biological responses of nuclear receptors [62].

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