P38 Mitogenactivated Protein Kinase

Protein kinases phosphorylate other proteins, and this action functions as a control switch for various cell activities. The switching functions make this family of proteins a very promising target for novel therapeutics. p38 mitogen-activated protein (MAP) kinase controls the production of growth factors and inflammatory cytokines, the molecules produced by the immune system that cause inflammation [54].

Fig. 12.6 H/D-Ex results of p38 MAP kinase at pH 7.0 at 25 °C with or without SB203580 [56]. Each block represents a pepsingenerated peptide. Each block has six time points and the level of deuterium incorporation is indicated by colors that vary according to the legend at the bottom right. Upper and middle blocks show the results without and with SB203580, respectively.

Lower blocks are the difference of the two deuterium incorporations. Dark blue indicates no difference with or without the ligand. The regions showing the difference are highlighted by black rectangles. Regions ofthe protein that contain amides that were not observed in the experiments are indicated in white [34].

Fig. 12.6 H/D-Ex results of p38 MAP kinase at pH 7.0 at 25 °C with or without SB203580 [56]. Each block represents a pepsingenerated peptide. Each block has six time points and the level of deuterium incorporation is indicated by colors that vary according to the legend at the bottom right. Upper and middle blocks show the results without and with SB203580, respectively.

Lower blocks are the difference of the two deuterium incorporations. Dark blue indicates no difference with or without the ligand. The regions showing the difference are highlighted by black rectangles. Regions ofthe protein that contain amides that were not observed in the experiments are indicated in white [34].

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