Microfluidic Systems Sensitivity High Speed

Presently, chip-based microfluidic technologies are being developed which efficiently incorporate low-flow liquid chromatographic methods with low-flow chip-based nanoelectrospray devices in very low dead volume systems [43]. By analyzing the GPC spin column eluates in a microfluidic HPLC mode, these chip-based technologies offer potentially promising methodologies for achieving the idealized goals of high throughput drug screening by minimizing sample consumption while using ESI-MS as the optimum universal detector, operating with multiple sprayers [44, 45] in parallel with duty cycles approaching 100% for the analysis of produced ions [46].

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