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be screened from a single 96-well plate of libraries per day. Only 10 pmol (0.5 mg) of protein is consumed per sample, and the ALIS screening campaign for Escherichia coli DHFR against 1500, 2500-member libraries, representing >3 500 000 compounds, consumed a total of 1.0 mg protein.

It is important to note that the same ALIS hardware and software used for combinatorial library screening is applicable to characterizing protein-ligand interactions using the methods described below.

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