Index

a absorption, distribution, metabolism and excretion (ADME) properties 402 accurate mass 9, 35, 38, 45, 47, 55, 324 7-acetoxy-1-methyl quinolinium iodide

(AMQI) 195 f. acetylcholine 292

acetylcholinesterase (AChE) 191 ff., 292 ff. N-acetylglucosamine 297 N-acetylglucosaminyltransferase V (GnT-V) 230 f.

adipocyte differentiation 390 affinity capture-MS 160

- noncovalent 160 affinity competition experiment

- definition 140 affinity ranking 134 f., 140 f.

affinity screening 157, 162, 165, 325, 367

- primary 164, 173

- ultra-high throughput 163 ff. affinity selection 121, 174, 179

affinity size exclusion 159 agonist 391

allele-specific expression 54 Alzheimer's disease 194, 313 D-amino acids 333 g-amino butyric acid (GABA) 268 ff.

- DL-3-amino-n-butyric acid 274

- transporter (GAT) 269

- mGAT1 268 ff. trans-4-aminocrotonic acid (TACA) 273 f. aminoglycosides 328 DL-4-amino-3-hydroxybutyric acid 273 f. (S)-4-amino-2-hydroxy butyric acid 273 f. 7-amino-4-methylcoumarin hydrochloride

(3-aminopropyl)triethoxysilane 237 cAMP 188, 288 antagonist 391

anterior pituitary somatotrope cell 386

anthrax lethal factor 298

antibiotic drug 310

antibody-antigen interaction 205

antidigoxigenin FAb 209 f.

antifungal drug 310

anxiety 269

apovinpocetin 46

area under the curve (AUC) 408

arterial hypertension 25

atmospheric pressure

atomic mass 55 ATP 137, 242, 390

automated ligand identification system (ALIS)

121, 125 ff., 135 f., 141, 148ff., 254 automatic gain control (AGC) 27 automation software 85 ff. average mass 55

b background spectrum 85 f. background subtraction 85 f. bacterial transcription 333 f. base peak 56 bicuculline 264 binding

- - perturbation 392

- quantitative 130 f.

binding (cont.)

- site classification 136

- stoichiometry 341, 345 bioactivity screening 193 f., 204, 212 bioanalysis 41 ff., 285, 289, 292, 299 bioanalytical assay 404, 413 bioinformatics 41, 54

biological efficacy 121, 134, 142 biological media 352, 359 biological response 390 biomarker 48 biosensor

- acoustic 253

- optical 229 biotin 188, 201 ff.

- derivatives 204 blood 322

bovine serum albumine (BSA) 76 ff., 294f.

brain 407

breakthrough 233, 237 f., 241

224f., 257ff., 269, 343, 349 butaclamol 257 ff.

C18 column 218 f., 342 see also restricted access C4 column 342 Caco-2 402, 405 Caenorhabditis elegans 52 f. calabar bean calcium 346 f., 351 ff. calibration 43 calibration factor 132 calmodulin (CaM) 351, 360 -apo 345 f., 351 f. -holo 346, 354 ff. calorimetry 253, 357 cancer

- drug 310

- hepatocellular 231

- invasion 188

- mammary 231

- pancreatic 231 capillary electrophoresis 160, 185

- affinity (ACE) 367 tris(2-carboxyethyl)phosphine hydrochloride

(TCEP) 381 carboxypeptidase 381

caspase-3 312 ff. caspase-5 316

cassette accelerated rapid rat screen (CARRS)

402, 408 ff. cathepsin B 188ff., 200 cell wall 322

central nervous system (CNS) disorder 95, 257

centrifugation 67 ff., 80 f., 259, 261, 268 channel electron multiplier (CEM) 39 charge residue (CR) model 16 f. charge state 15 chelerythrine chloride 242 chemical etching 290 chemical ionization (CI) 10 ff.

- positive (PCI) 12, 56 chemical noise 76, 85 chemotypes 168 Cheng-Prusoff equation 272 chinese herbs 243 chlorpromazine 258 ff. choline 292

circular dichroism 349, 357 collagenase 106 collision cell 24f., 35, 404 collision energy 25 collision gas 35

collision-induced dissociation (CID) 13, 25,

29, 31, 37, 57 continuous-flow system 185 f., 200

- on-line 202 ff. conversion dynode 40 Coomassie

- staining 366 corona discharge 18 f. curtain gas 12 f.

a-cyano-4-hydroxycinnamic acid 286 cyanuric chloride 294 f. cyclohexane 5 cysteamine 306 ff. cysteine 306 ff., 342, 362 cytochrome c 294 cytochrome P450 178, 405 f. cytomegalovirus protease (CMVP) 67 f., 84, 99 ff., 108 ff.

d daidzein 19 f. DAMGO 266 DAPI 93

data analysis, automated 383

data dependent acquisition (DDA) 41, 46 data reduction 85

deconvolution 16, 167 f., 173 ff., 307, 365 dehydroisoandrosterone 229 deoxyuridine monophosphate (dUMP) 310

dependent scan 46 depression 269

desorption electrospray (DESI) 12, 20f. desorption/ionization on porous silicon

- photo diode array 20 detection emitter plate 36 detector 38

detector dead time 35 diagnostic monitoring 54 dibromoquinazolone (DBQ) 99, 108 ff. difluoromethyl ketone inhibitor (DFMK)

67 f., 84 digestion 360, 381

- enzymatic 50

- on-plate 294 digoxigenin 205 f. digoxin 205 f., 209 ff.

dihydrofolate reductase (DHFR) 127 ff., 137, 237 f.

2,5-dihydroxy benzoic acid 286 ff.

direct analysis in real time (DART) 12, 20

direct current (DC) potential 23, 30

direct liquid interface (DLI) 3

discharge lamp 19

distamycin 93

disulfide linker 306 ff., 315

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