Human growth hormone (hGH) is a 191-amino-acid polypeptide that is released from anterior pituitary somatotrope cells. The hormone functions to promote linear growth during adolescence and modulate many physiological functions after completion of growth. Since 1984, somatropin (recombinant DNA-derived hGH) therapy has been applied in the treatment of growth hormone-deficient children. hGH is known to exhibit a distinct conformation at an acidic pH when compared to neutral pH . Although the molecular conformations at acid and neutral pH share virtually identical extents of secondary structure, differences in the tertiary structure have been observed. The less stable acidic conformation is also implicated as the intermediate for undesirable aggregation .
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